Recent Advances in the Synthesis and Applications of 2-Arylbenzothiazoles
Abstract This review firstly covers the applications of 2-arylbenzothiazoles as amyloid imaging agents, antitumor agents, and organic luminescent materials. Then we review the recent advances in the synthesis of 2-arylbenzothiazole derivatives. On the one hand, we introduce the approaches for constr...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2020-12, Vol.52 (23), p.3530-3548 |
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| container_title | Synthesis (Stuttgart) |
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| creator | Gan, Fuqiang Luo, Puying Lin, Junyue Ding, Qiuping |
| description | Abstract
This review firstly covers the applications of 2-arylbenzothiazoles as amyloid imaging agents, antitumor agents, and organic luminescent materials. Then we review the recent advances in the synthesis of 2-arylbenzothiazole derivatives. On the one hand, we introduce the approaches for construction of the 2-arylbenzothiazole core, including the following categories: (i) classic condensation of 2-aminothiophenols, (ii) direct arylation of benzothiazoles, (iii) intramolecular cyclization of thiobenzanilides, and (iv) tandem cyclization of anilines/ nitroarenes with elemental sulfur or sulfides. On the other hand, the transition-metal-catalyzed direct C–H functionalizations of 2-arylbenzothiazoles are also involved in this review.
1 Introduction
2 Applications of 2-Arylbenzothiazoles
3 Construction of the 2-Arylbenzothiazole Core
4 Synthesis 2-Arylbenzothiazoles via Direct C–H Functionalization
5 Conclusion |
| doi_str_mv | 10.1055/s-0040-1707208 |
| format | Article |
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This review firstly covers the applications of 2-arylbenzothiazoles as amyloid imaging agents, antitumor agents, and organic luminescent materials. Then we review the recent advances in the synthesis of 2-arylbenzothiazole derivatives. On the one hand, we introduce the approaches for construction of the 2-arylbenzothiazole core, including the following categories: (i) classic condensation of 2-aminothiophenols, (ii) direct arylation of benzothiazoles, (iii) intramolecular cyclization of thiobenzanilides, and (iv) tandem cyclization of anilines/ nitroarenes with elemental sulfur or sulfides. On the other hand, the transition-metal-catalyzed direct C–H functionalizations of 2-arylbenzothiazoles are also involved in this review.
1 Introduction
2 Applications of 2-Arylbenzothiazoles
3 Construction of the 2-Arylbenzothiazole Core
4 Synthesis 2-Arylbenzothiazoles via Direct C–H Functionalization
5 Conclusion</description><identifier>ISSN: 0039-7881</identifier><identifier>EISSN: 1437-210X</identifier><identifier>DOI: 10.1055/s-0040-1707208</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag</publisher><subject>short review</subject><ispartof>Synthesis (Stuttgart), 2020-12, Vol.52 (23), p.3530-3548</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-488c71fa9474bc6d96966069f5f31dc195785001f9677a96b91917d6b89f91ec3</citedby><cites>FETCH-LOGICAL-c277t-488c71fa9474bc6d96966069f5f31dc195785001f9677a96b91917d6b89f91ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1707208.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0040-1707208$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,27901,27902,54534,54535</link.rule.ids></links><search><creatorcontrib>Gan, Fuqiang</creatorcontrib><creatorcontrib>Luo, Puying</creatorcontrib><creatorcontrib>Lin, Junyue</creatorcontrib><creatorcontrib>Ding, Qiuping</creatorcontrib><title>Recent Advances in the Synthesis and Applications of 2-Arylbenzothiazoles</title><title>Synthesis (Stuttgart)</title><addtitle>Synthesis</addtitle><description>Abstract
This review firstly covers the applications of 2-arylbenzothiazoles as amyloid imaging agents, antitumor agents, and organic luminescent materials. Then we review the recent advances in the synthesis of 2-arylbenzothiazole derivatives. On the one hand, we introduce the approaches for construction of the 2-arylbenzothiazole core, including the following categories: (i) classic condensation of 2-aminothiophenols, (ii) direct arylation of benzothiazoles, (iii) intramolecular cyclization of thiobenzanilides, and (iv) tandem cyclization of anilines/ nitroarenes with elemental sulfur or sulfides. On the other hand, the transition-metal-catalyzed direct C–H functionalizations of 2-arylbenzothiazoles are also involved in this review.
1 Introduction
2 Applications of 2-Arylbenzothiazoles
3 Construction of the 2-Arylbenzothiazole Core
4 Synthesis 2-Arylbenzothiazoles via Direct C–H Functionalization
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This review firstly covers the applications of 2-arylbenzothiazoles as amyloid imaging agents, antitumor agents, and organic luminescent materials. Then we review the recent advances in the synthesis of 2-arylbenzothiazole derivatives. On the one hand, we introduce the approaches for construction of the 2-arylbenzothiazole core, including the following categories: (i) classic condensation of 2-aminothiophenols, (ii) direct arylation of benzothiazoles, (iii) intramolecular cyclization of thiobenzanilides, and (iv) tandem cyclization of anilines/ nitroarenes with elemental sulfur or sulfides. On the other hand, the transition-metal-catalyzed direct C–H functionalizations of 2-arylbenzothiazoles are also involved in this review.
1 Introduction
2 Applications of 2-Arylbenzothiazoles
3 Construction of the 2-Arylbenzothiazole Core
4 Synthesis 2-Arylbenzothiazoles via Direct C–H Functionalization
5 Conclusion</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag</pub><doi>10.1055/s-0040-1707208</doi><tpages>19</tpages></addata></record> |
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| language | eng |
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| source | Thieme Connect Journals |
| subjects | short review |
| title | Recent Advances in the Synthesis and Applications of 2-Arylbenzothiazoles |
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