BF3·OEt2-Catalyzed Synthesis of anti-β-(N-Arylamino)-α-hydroxynitriles by Regio- and Diastereospecific Ring Opening of 3-Aryloxirane-2-carbonitriles with Anilines

Abstract A safe and convenient synthetic method to anti -β-( N -arylamino)-α-hydroxynitriles from 3-aryloxirane-2-carbonitriles and anilines was developed under the catalysis of BF 3 ·OEt 2 in ethanol. In this method, BF 3 ·OEt 2 first reacts with ethanol to produce the true catalyst of super­ acid...

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Veröffentlicht in:	Synthesis (Stuttgart) 2020-02, Vol.52 (4), p.602-608
Hauptverfasser:	Xu, Chuangchuang, Lu, Yang, Xu, Kaini, Xu, Jiaxi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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