Benzyl Acetylcarbamate Potassium Salt (BENAC-K): A Simple Nucleophilic N-Acetamide Equivalent

Benzyl Acetylcarbamate Potassium Salt (BENAC-K): A Simple Nucleophilic N-Acetamide Equivalent

Abstract Benzyl acetylcarbamate potassium salt (BENAC-K) has been developed as a simple nucleophilic acetamide equivalent. A broad variety of alkyl halides were converted into benzyloxycarbonyl-protected N -alkylacetamides in high yields by simple treatment with an almost equimolar (1.1 equiv) amoun...

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Veröffentlicht in:Synthesis (Stuttgart) 2019-10, Vol.51 (19), p.3638-3650
Hauptverfasser: Sakai, Takeo, Tatematsu, Toshiki, Fukuta, Ayumi, Kasai, Satomi, Hayashi, Kahori, Mori, Yuji
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container_end_page 3650
container_issue 19
container_start_page 3638
container_title Synthesis (Stuttgart)
container_volume 51
creator Sakai, Takeo
Tatematsu, Toshiki
Fukuta, Ayumi
Kasai, Satomi
Hayashi, Kahori
Mori, Yuji
description Abstract Benzyl acetylcarbamate potassium salt (BENAC-K) has been developed as a simple nucleophilic acetamide equivalent. A broad variety of alkyl halides were converted into benzyloxycarbonyl-protected N -alkylacetamides in high yields by simple treatment with an almost equimolar (1.1 equiv) amount of BENAC-K in a polar solvent.
doi_str_mv 10.1055/s-0039-1690097
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title Benzyl Acetylcarbamate Potassium Salt (BENAC-K): A Simple Nucleophilic N-Acetamide Equivalent
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