Chemoenzymatic Synthesis of Modified 2′-Deoxy-2′-fluoro-β-d-arabinofuranosyl Benzimidazoles and Evaluation of Their Activity Against Herpes Simplex Virus Type 1

Abstract 1-(2′-Deoxy-2′-fluoro-β- d -arabinofuranosyl)benzimidazoles containing 4,6-difluoro-, 4,5,6-trifluoro-, 5-fluoro-6-methoxy-, and 5-methoxy-4,6-difluorobenzimidazole fragments were synthesized by using purine nucleoside phosphorylase-catalyzed chemoenzymatic approach. As expected, enzymatic...

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Veröffentlicht in:	Synthesis (Stuttgart) 2017-03, Vol.49 (5), p.1043-1052
Hauptverfasser:	Kharitonova, Maria I., Аntonov, Konstantin V., Fateev, Ilya V., Berzina, Мaria Ya, Kaushin, Alexei L., Paramonov, Alexander S., Kotovskaya, Svetlana K., Аndronova, Valeria L., Konstantinova, Irina D., Galegov, Georgiy A., Charushin, Valery N., Miroshnikov, Anatoly I.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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