Tandem and One-Pot Hydroformylation/Michael Reactions of Acrylates
Abstract The combination of various reactions in one operational step leads to many advantages in synthetic strategies, such as a lower consumption of resources, effort, and time, when intermittent workup and purification steps can be avoided. The hydroformylation reaction of acrylates gives access...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2017-02, Vol.49 (4), p.925-932 |
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| container_title | Synthesis (Stuttgart) |
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| creator | Quintero-Duque, Samuel Fleischer, Ivana |
| description | Abstract
The combination of various reactions in one operational step leads to many advantages in synthetic strategies, such as a lower consumption of resources, effort, and time, when intermittent workup and purification steps can be avoided. The hydroformylation reaction of acrylates gives access to 2-formylpropanoates, which thanks to their structural features constitute useful intermediates in the synthesis of more complex compounds. Herein, we report a simple and convenient one-pot strategy to synthesize functionalized carbonyl compounds starting from these readily available substrates, via tandem or one-pot hydroformylation, Michael addition, and aldol reactions. |
| doi_str_mv | 10.1055/s-0036-1588394 |
| format | Article |
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The combination of various reactions in one operational step leads to many advantages in synthetic strategies, such as a lower consumption of resources, effort, and time, when intermittent workup and purification steps can be avoided. The hydroformylation reaction of acrylates gives access to 2-formylpropanoates, which thanks to their structural features constitute useful intermediates in the synthesis of more complex compounds. Herein, we report a simple and convenient one-pot strategy to synthesize functionalized carbonyl compounds starting from these readily available substrates, via tandem or one-pot hydroformylation, Michael addition, and aldol reactions.</description><identifier>ISSN: 0039-7881</identifier><identifier>EISSN: 1437-210X</identifier><identifier>DOI: 10.1055/s-0036-1588394</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag</publisher><ispartof>Synthesis (Stuttgart), 2017-02, Vol.49 (4), p.925-932</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1588394.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0036-1588394$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,777,781,3004,3005,27905,27906,54540,54541</link.rule.ids></links><search><creatorcontrib>Quintero-Duque, Samuel</creatorcontrib><creatorcontrib>Fleischer, Ivana</creatorcontrib><title>Tandem and One-Pot Hydroformylation/Michael Reactions of Acrylates</title><title>Synthesis (Stuttgart)</title><addtitle>Synthesis</addtitle><description>Abstract
The combination of various reactions in one operational step leads to many advantages in synthetic strategies, such as a lower consumption of resources, effort, and time, when intermittent workup and purification steps can be avoided. The hydroformylation reaction of acrylates gives access to 2-formylpropanoates, which thanks to their structural features constitute useful intermediates in the synthesis of more complex compounds. Herein, we report a simple and convenient one-pot strategy to synthesize functionalized carbonyl compounds starting from these readily available substrates, via tandem or one-pot hydroformylation, Michael addition, and aldol reactions.</description><issn>0039-7881</issn><issn>1437-210X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLAzEUhYMoOFa3rucPpM1zkixrUStUKlLBXcjkQafMTCQZF_PvnaHdurkH7rnncPkAeMRoiRHnqwwRohXEXEqq2BUoMKMCEoy-r0ExWQoKKfEtuMv5hBAShKoCPB1M73xXTrPc9x5-xKHcji7FEFM3tmZoYr96b-zR-Lb89MbOi1zGUK5tmn2f78FNMG32DxddgK-X58NmC3f717fNegctoWSAkrCAiAlSGEeoodypUAkSnHGBCMEDY87VHlW2ZnXAVkpFmQ1KqIo5pjhdgOW516aYc_JB_6SmM2nUGOmZgM56JqAvBKYAPAeGY-M7r0_xN_XTh__d_wHh8FzS</recordid><startdate>20170215</startdate><enddate>20170215</enddate><creator>Quintero-Duque, Samuel</creator><creator>Fleischer, Ivana</creator><general>Georg Thieme Verlag</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20170215</creationdate><title>Tandem and One-Pot Hydroformylation/Michael Reactions of Acrylates</title><author>Quintero-Duque, Samuel ; Fleischer, Ivana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c232t-824f02af87ad23a35d9f672fdadf2775f44ddbe06cb4bf1c88934cf97964d4953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quintero-Duque, Samuel</creatorcontrib><creatorcontrib>Fleischer, Ivana</creatorcontrib><collection>CrossRef</collection><jtitle>Synthesis (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quintero-Duque, Samuel</au><au>Fleischer, Ivana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tandem and One-Pot Hydroformylation/Michael Reactions of Acrylates</atitle><jtitle>Synthesis (Stuttgart)</jtitle><addtitle>Synthesis</addtitle><date>2017-02-15</date><risdate>2017</risdate><volume>49</volume><issue>4</issue><spage>925</spage><epage>932</epage><pages>925-932</pages><issn>0039-7881</issn><eissn>1437-210X</eissn><abstract>Abstract
The combination of various reactions in one operational step leads to many advantages in synthetic strategies, such as a lower consumption of resources, effort, and time, when intermittent workup and purification steps can be avoided. The hydroformylation reaction of acrylates gives access to 2-formylpropanoates, which thanks to their structural features constitute useful intermediates in the synthesis of more complex compounds. Herein, we report a simple and convenient one-pot strategy to synthesize functionalized carbonyl compounds starting from these readily available substrates, via tandem or one-pot hydroformylation, Michael addition, and aldol reactions.</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag</pub><doi>10.1055/s-0036-1588394</doi><tpages>8</tpages></addata></record> |
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| ispartof | Synthesis (Stuttgart), 2017-02, Vol.49 (4), p.925-932 |
| issn | 0039-7881 1437-210X |
| language | eng |
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| source | Thieme Connect Journals |
| title | Tandem and One-Pot Hydroformylation/Michael Reactions of Acrylates |
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