A Practical and Scalable Synthesis of (S)- and (R)-1-(Dimethoxyphosphoryl)allyl Methyl Carbonates

Abstract The preparation of ( S )- and ( R )-1-(dimethoxyphosphoryl)allyl methyl carbonates is achieved on multigram scale from commercially available dimethyl phosphite and acrolein in three steps. The key steps involve an asymmetric Pudovik reaction and enzyme-catalyzed kinetic resolution.

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Veröffentlicht in:	Synthesis (Stuttgart) 2015-12, Vol.47 (23), p.3669-3672
Hauptverfasser:	Roy, Sudeshna, Sutivisedsak, Nongnuch, Hamper, Bruce C., Lyss, Alexander M., Spilling, Christopher D.
Format:	Artikel
Sprache:	eng
Schlagworte:	psp
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creator	Roy, Sudeshna Sutivisedsak, Nongnuch Hamper, Bruce C. Lyss, Alexander M. Spilling, Christopher D.
description	Abstract The preparation of ( S )- and ( R )-1-(dimethoxyphosphoryl)allyl methyl carbonates is achieved on multigram scale from commercially available dimethyl phosphite and acrolein in three steps. The key steps involve an asymmetric Pudovik reaction and enzyme-catalyzed kinetic resolution.
doi_str_mv	10.1055/s-0035-1560487
format	Article
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title	A Practical and Scalable Synthesis of (S)- and (R)-1-(Dimethoxyphosphoryl)allyl Methyl Carbonates
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