An Approach to the Synthesis of Pyrimido[b]azepines via Ruthenium-Catalyzed Ring-Closing Metathesis
Abstract A highly efficient approach to the synthesis of a series of pyrimido[ b ]azepines has been developed with 5-allyl-2,4,6-trichloropyrimidine as the starting material in six or seven steps via a ring-closing metathesis (RCM) reaction. The absolute configuration of the key intermediate pyrimid...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2015-11, Vol.47 (21), p.3292-3300 |
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| container_title | Synthesis (Stuttgart) |
| container_volume | 47 |
| creator | Zhang, Tong-Bo Yang, Quan-Zhi Cao, Yuan-Yuan Wu, Shao-Tong Zhang, Yu Guo, Ying Zhao, Jian-Xiong Sun, Xue-Feng Zhang, Zhi-Li Tian, Chao Liu, Jun-Yi Wang, Xiao-Wei |
| description | Abstract
A highly efficient approach to the synthesis of a series of pyrimido[
b
]azepines has been developed with 5-allyl-2,4,6-trichloropyrimidine as the starting material in six or seven steps via a ring-closing metathesis (RCM) reaction. The absolute configuration of the key intermediate pyrimido[4,5-
b
]azepine was ascertained by X-ray crystal structure analysis. |
| doi_str_mv | 10.1055/s-0034-1381009 |
| format | Article |
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A highly efficient approach to the synthesis of a series of pyrimido[
b
]azepines has been developed with 5-allyl-2,4,6-trichloropyrimidine as the starting material in six or seven steps via a ring-closing metathesis (RCM) reaction. The absolute configuration of the key intermediate pyrimido[4,5-
b
]azepine was ascertained by X-ray crystal structure analysis.</description><identifier>ISSN: 0039-7881</identifier><identifier>EISSN: 1437-210X</identifier><identifier>DOI: 10.1055/s-0034-1381009</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag</publisher><ispartof>Synthesis (Stuttgart), 2015-11, Vol.47 (21), p.3292-3300</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-62f161f927f2da0e61a46d2bc0b8362a943e3b0cbe7846eb080c6a3e0d0e875c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0034-1381009.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0034-1381009$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3008,3009,27915,27916,54550,54551</link.rule.ids></links><search><creatorcontrib>Zhang, Tong-Bo</creatorcontrib><creatorcontrib>Yang, Quan-Zhi</creatorcontrib><creatorcontrib>Cao, Yuan-Yuan</creatorcontrib><creatorcontrib>Wu, Shao-Tong</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Guo, Ying</creatorcontrib><creatorcontrib>Zhao, Jian-Xiong</creatorcontrib><creatorcontrib>Sun, Xue-Feng</creatorcontrib><creatorcontrib>Zhang, Zhi-Li</creatorcontrib><creatorcontrib>Tian, Chao</creatorcontrib><creatorcontrib>Liu, Jun-Yi</creatorcontrib><creatorcontrib>Wang, Xiao-Wei</creatorcontrib><title>An Approach to the Synthesis of Pyrimido[b]azepines via Ruthenium-Catalyzed Ring-Closing Metathesis</title><title>Synthesis (Stuttgart)</title><addtitle>Synthesis</addtitle><description>Abstract
A highly efficient approach to the synthesis of a series of pyrimido[
b
]azepines has been developed with 5-allyl-2,4,6-trichloropyrimidine as the starting material in six or seven steps via a ring-closing metathesis (RCM) reaction. The absolute configuration of the key intermediate pyrimido[4,5-
b
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A highly efficient approach to the synthesis of a series of pyrimido[
b
]azepines has been developed with 5-allyl-2,4,6-trichloropyrimidine as the starting material in six or seven steps via a ring-closing metathesis (RCM) reaction. The absolute configuration of the key intermediate pyrimido[4,5-
b
]azepine was ascertained by X-ray crystal structure analysis.</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag</pub><doi>10.1055/s-0034-1381009</doi><tpages>9</tpages></addata></record> |
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| source | Thieme Connect Journals |
| title | An Approach to the Synthesis of Pyrimido[b]azepines via Ruthenium-Catalyzed Ring-Closing Metathesis |
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