Trifluoroborane-Catalyzed C–H Functionalization/S–H Insertion Reaction: Construction of N,S-Acetal Quaternary Centers

Trifluoroborane-Catalyzed C–H Functionalization/S–H Insertion Reaction: Construction of N,S-Acetal Quaternary Centers

Abstract The trifluoroborane-catalyzed C–H functionalization/S–H insertion reaction of α-diazophosphonates with thiols has been developed. A plausible reaction mechanism has been proposed to understand the combined reaction. This process provides straightforward access to N , S -acetals containing q...

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Veröffentlicht in:Synthesis (Stuttgart) 2015-06, Vol.47 (11), p.1669-1677
Hauptverfasser: Cai, Yan, Ge, Haihong, Sun, Weize, Miao, Zhiwei
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The trifluoroborane-catalyzed C–H functionalization/S–H insertion reaction of α-diazophosphonates with thiols has been developed. A plausible reaction mechanism has been proposed to understand the combined reaction. This process provides straightforward access to N , S -acetals containing quaternary centers in moderate to good yields and chemoselectivity.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0034-1380384