Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-d-aspartate Receptor Allosteric Modulators

Abstract 9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the N -methyl- d -aspartate (NMDA) receptor. This receptor is activated by the excitatory neurotransmitter l -glutamate and has been implicated in a range of neurological disorders suc...

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Veröffentlicht in:	Synthesis (Stuttgart) 2015-06, Vol.47 (11), p.1593-1610
Hauptverfasser:	Irvine, Mark W., Fang, Guangyu, Eaves, Richard, Mayo-Martin, Maria B., Burnell, Erica S., Costa, Blaise M., Culley, Georgia R., Volianskis, Arturas, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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