Sandmeyer Trifluoromethylation

Abstract A range of benzotrifluorides are conveniently accessible in high yields from widely available (hetero)aromatic amines and the inexpensive trifluoromethylating agent TMSCF 3 through a copper-mediated Sandmeyer trifluoromethylation reaction. Two practical procedures are presented. In the firs...

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Veröffentlicht in:	Synthesis (Stuttgart) 2014-09, Vol.46 (17), p.2283-2286
Hauptverfasser:	Danoun, Grégory, Bayarmagnai, Bilguun, Grünberg, Matthias F., Matheis, Christian, Risto, Eugen, Gooßen, Lukas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	practical synthetic procedures
Online-Zugang:	Volltext
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Zusammenfassung:	Abstract A range of benzotrifluorides are conveniently accessible in high yields from widely available (hetero)aromatic amines and the inexpensive trifluoromethylating agent TMSCF 3 through a copper-mediated Sandmeyer trifluoromethylation reaction. Two practical procedures are presented. In the first, the diazonium salts are preformed in an extra reaction step, in the second approach the diazotization and the trifluoromethylation are combined into a one-pot procedure.
ISSN:	0039-7881 1437-210X
DOI:	10.1055/s-0034-1378549