Synthesis of Novel Thymine-β-lactam Hybrids and Evaluation of Their Antitumor Activity

Abstract Trimethylene-tethered thymine-β-lactam and thymine-bis-β-lactam chimeras were prepared as novel classes of hybrid systems through selective mono- or bis-N-alkylation of thymine with cis -1-(3-bromopropyl)-β-lactams. In addition, acidic methanolysis of the β-lactam nucleus in these systems p...

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Veröffentlicht in:	Synthesis (Stuttgart) 2014-09, Vol.46 (18), p.2436-2444
Hauptverfasser:	Piens, Nicola, De Vreese, Rob, De Neve, Nympha, Van Hecke, Kristof, Balzarini, Jan, De Kimpe, Norbert, D’hooghe, Matthias
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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