Catalyst- and Additive-Free Synthesis of Fluoroalkoxyquinolines

Catalyst- and Additive-Free Synthesis of Fluoroalkoxyquinolines

Abstract A nucleophilic substitution approach has been developed for the synthesis of C4 fluoroalkoxyquinolines from 4-haloquinolines by utilizing hexafluoro-2-propanol and trifluoroethanol as nucleophiles. The method is also applicable for 2-chloroquinolines, 1-chloroisoquinoline, and 2-chlorobenzi...

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Veröffentlicht in:Synthesis (Stuttgart) 2021-11, Vol.53 (21), p.4124-4130
Hauptverfasser: Dhiman, Ankit Kumar, Kumar, Rohit, Sharma, Upendra
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creator Dhiman, Ankit Kumar
Kumar, Rohit
Sharma, Upendra
description Abstract A nucleophilic substitution approach has been developed for the synthesis of C4 fluoroalkoxyquinolines from 4-haloquinolines by utilizing hexafluoro-2-propanol and trifluoroethanol as nucleophiles. The method is also applicable for 2-chloroquinolines, 1-chloroisoquinoline, and 2-chlorobenzimidazole. Control experiments revealed that substitution occurs only at the C2 and C4 positions of quinolines.
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