Nucleophilic H-Phosphites, H-Phosphinates, and H-Phosphine Oxides in Organic Reactions

Abstract P(O)–H compounds like H-phosphites, H-phosphinates, and H-phosphine oxides are widely used as nucleophiles. Herein, their reactions with unsaturated compounds, C–H activation, the Hirao reaction, P–C, P–S, P–O, P–N, and P–F couplings are thoroughly discussed and summarized. This review will...

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Veröffentlicht in:	Synthesis (Stuttgart) 2021-10, Vol.53 (20), p.3683-3698
Hauptverfasser:	Wang, Zhan-Yong, Guo, Qi, Xu, Shaohong, Wang, Kai-Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	short review
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creator	Wang, Zhan-Yong Guo, Qi Xu, Shaohong Wang, Kai-Kai
description	Abstract P(O)–H compounds like H-phosphites, H-phosphinates, and H-phosphine oxides are widely used as nucleophiles. Herein, their reactions with unsaturated compounds, C–H activation, the Hirao reaction, P–C, P–S, P–O, P–N, and P–F couplings are thoroughly discussed and summarized. This review will focus on their reactions with alkenes, alkynes, enamides, propynoic acids, epoxide, arynes, arenes, quinones, isothiocyanates, diazo compounds, aldehydes, ketones, imines, pyridines, acid derivatives, carbocations, aryl halides, dibromoalkenes, disulfides, thiosulfates, sulfonyl chlorides, iodonium salts, amines, alcohols, and thiols. 1 Introduction 2 Addition to Alkenes/Alkynes 3 Addition to Other Unsaturated Compounds 4 Coupling with Carbocations 5 Phosphorylation of Aryl C–H Bonds 6 Hirao Reaction 7 P–S, P–O, P–N, or P–F Coupling 8 Conclusions
doi_str_mv	10.1055/a-1511-0382
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title	Nucleophilic H-Phosphites, H-Phosphinates, and H-Phosphine Oxides in Organic Reactions
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