Antioxidant, Cytotoxic, and Acetylcholinesterase Inhibitory Activities of Withanolides from Datura quercifolia
Abstract Five withanolides identified as daturalactone (1) , withanicandrin (2) , withanolide B (3) , nicandrin B (4) , and daturalactone 2 (5) were isolated from the aerial parts (flowers, leaves, and stems) of Datura quercifolia Kunth. Their structures were determined by analysis of the IR, MS, 1D...
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| Veröffentlicht in: | Planta Medica International Open (Online) 2020-05, Vol.7 (2), p.e68-e72 |
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| creator | Jasso, Christian Nieto-Camacho, Antonio Ramírez-Apan, MaríaTeresa Martínez, Mahinda Maldonado, Emma |
| description | Abstract
Five withanolides identified as daturalactone
(1)
, withanicandrin
(2)
, withanolide B
(3)
, nicandrin B
(4)
, and
daturalactone 2
(5)
were isolated from the aerial parts (flowers,
leaves, and stems) of
Datura quercifolia
Kunth. Their structures were
determined by analysis of the IR, MS, 1D and 2D NMR spectra. All the
isolates were evaluated for their cytotoxic and antioxidant activities, as
well as for their capacity to inhibit the activity of the
acetylcholinesterase enzyme (AChE). As result, the five withanolides showed
weak cytotoxic and pro-oxidant activities, however, they displayed a
relevant inhibitory activity against AChE, as indicated by the
IC
50
values ranging from 1.51 to 12.11
µ
M. The
differences in AChE inhibition seem to be related to the functional group at
C-12. |
| doi_str_mv | 10.1055/a-1156-4229 |
| format | Article |
| fullrecord | <record><control><sourceid>thieme_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1055_a_1156_4229</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1055_a_1156_4229</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1509-d538b19bc9fe1f5a8abb08c12ad3904a52ba7cebfc4eb3c78a00323f2ba709613</originalsourceid><addsrcrecordid>eNptkM1OwzAQhC0EElXpiRfwGRqwndiNj1X5q1SJC4hjtHZsxai1wXYQeXsStUdOu7PzaTUahK4puaOE83soKOWiqBiTZ2jGOJGFEFycn3bJRHWJFik5RUrBuFwxPkN-7bMLv64Fn5d4M-SQR6WXGHyL19rkYa-7sHfepGwiJIO3vnPK5RCH0c_ux2VnEg4Wf7jcgR_ZdtQ2hgN-gNxHwN-9idrZ0YErdGFhn8ziNOfo_enxbfNS7F6ft5v1rtB0ytryslZUKi2toZZDDUqRWlMGbSlJBZwpWGmjrK6MKvWqBkJKVtrpTKSg5RzdHv_qGFKKxjZf0R0gDg0lzdRWA83UVjO1NdI3Rzp3zhxM8xn66Md4_8J_IvVtFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Antioxidant, Cytotoxic, and Acetylcholinesterase Inhibitory Activities of Withanolides from Datura quercifolia</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Thieme Connect Journals Open Access</source><creator>Jasso, Christian ; Nieto-Camacho, Antonio ; Ramírez-Apan, MaríaTeresa ; Martínez, Mahinda ; Maldonado, Emma</creator><creatorcontrib>Jasso, Christian ; Nieto-Camacho, Antonio ; Ramírez-Apan, MaríaTeresa ; Martínez, Mahinda ; Maldonado, Emma</creatorcontrib><description>Abstract
Five withanolides identified as daturalactone
(1)
, withanicandrin
(2)
, withanolide B
(3)
, nicandrin B
(4)
, and
daturalactone 2
(5)
were isolated from the aerial parts (flowers,
leaves, and stems) of
Datura quercifolia
Kunth. Their structures were
determined by analysis of the IR, MS, 1D and 2D NMR spectra. All the
isolates were evaluated for their cytotoxic and antioxidant activities, as
well as for their capacity to inhibit the activity of the
acetylcholinesterase enzyme (AChE). As result, the five withanolides showed
weak cytotoxic and pro-oxidant activities, however, they displayed a
relevant inhibitory activity against AChE, as indicated by the
IC
50
values ranging from 1.51 to 12.11
µ
M. The
differences in AChE inhibition seem to be related to the functional group at
C-12.</description><identifier>ISSN: 2509-9264</identifier><identifier>EISSN: 2509-6656</identifier><identifier>DOI: 10.1055/a-1156-4229</identifier><language>eng</language><publisher>Stuttgart · New York: Georg Thieme Verlag KG</publisher><subject>Original Papers</subject><ispartof>Planta Medica International Open (Online), 2020-05, Vol.7 (2), p.e68-e72</ispartof><rights>Thieme. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1509-d538b19bc9fe1f5a8abb08c12ad3904a52ba7cebfc4eb3c78a00323f2ba709613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1156-4229.pdf$$EPDF$$P50$$Gthieme$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/a-1156-4229$$EHTML$$P50$$Gthieme$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,20896,27929,27930,54592,54620</link.rule.ids></links><search><creatorcontrib>Jasso, Christian</creatorcontrib><creatorcontrib>Nieto-Camacho, Antonio</creatorcontrib><creatorcontrib>Ramírez-Apan, MaríaTeresa</creatorcontrib><creatorcontrib>Martínez, Mahinda</creatorcontrib><creatorcontrib>Maldonado, Emma</creatorcontrib><title>Antioxidant, Cytotoxic, and Acetylcholinesterase Inhibitory Activities of Withanolides from Datura quercifolia</title><title>Planta Medica International Open (Online)</title><description>Abstract
Five withanolides identified as daturalactone
(1)
, withanicandrin
(2)
, withanolide B
(3)
, nicandrin B
(4)
, and
daturalactone 2
(5)
were isolated from the aerial parts (flowers,
leaves, and stems) of
Datura quercifolia
Kunth. Their structures were
determined by analysis of the IR, MS, 1D and 2D NMR spectra. All the
isolates were evaluated for their cytotoxic and antioxidant activities, as
well as for their capacity to inhibit the activity of the
acetylcholinesterase enzyme (AChE). As result, the five withanolides showed
weak cytotoxic and pro-oxidant activities, however, they displayed a
relevant inhibitory activity against AChE, as indicated by the
IC
50
values ranging from 1.51 to 12.11
µ
M. The
differences in AChE inhibition seem to be related to the functional group at
C-12.</description><subject>Original Papers</subject><issn>2509-9264</issn><issn>2509-6656</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><recordid>eNptkM1OwzAQhC0EElXpiRfwGRqwndiNj1X5q1SJC4hjtHZsxai1wXYQeXsStUdOu7PzaTUahK4puaOE83soKOWiqBiTZ2jGOJGFEFycn3bJRHWJFik5RUrBuFwxPkN-7bMLv64Fn5d4M-SQR6WXGHyL19rkYa-7sHfepGwiJIO3vnPK5RCH0c_ux2VnEg4Wf7jcgR_ZdtQ2hgN-gNxHwN-9idrZ0YErdGFhn8ziNOfo_enxbfNS7F6ft5v1rtB0ytryslZUKi2toZZDDUqRWlMGbSlJBZwpWGmjrK6MKvWqBkJKVtrpTKSg5RzdHv_qGFKKxjZf0R0gDg0lzdRWA83UVjO1NdI3Rzp3zhxM8xn66Md4_8J_IvVtFA</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Jasso, Christian</creator><creator>Nieto-Camacho, Antonio</creator><creator>Ramírez-Apan, MaríaTeresa</creator><creator>Martínez, Mahinda</creator><creator>Maldonado, Emma</creator><general>Georg Thieme Verlag KG</general><scope>0U6</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>202005</creationdate><title>Antioxidant, Cytotoxic, and Acetylcholinesterase Inhibitory Activities of Withanolides from Datura quercifolia</title><author>Jasso, Christian ; Nieto-Camacho, Antonio ; Ramírez-Apan, MaríaTeresa ; Martínez, Mahinda ; Maldonado, Emma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1509-d538b19bc9fe1f5a8abb08c12ad3904a52ba7cebfc4eb3c78a00323f2ba709613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Original Papers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jasso, Christian</creatorcontrib><creatorcontrib>Nieto-Camacho, Antonio</creatorcontrib><creatorcontrib>Ramírez-Apan, MaríaTeresa</creatorcontrib><creatorcontrib>Martínez, Mahinda</creatorcontrib><creatorcontrib>Maldonado, Emma</creatorcontrib><collection>Thieme Connect Journals Open Access</collection><collection>CrossRef</collection><jtitle>Planta Medica International Open (Online)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jasso, Christian</au><au>Nieto-Camacho, Antonio</au><au>Ramírez-Apan, MaríaTeresa</au><au>Martínez, Mahinda</au><au>Maldonado, Emma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant, Cytotoxic, and Acetylcholinesterase Inhibitory Activities of Withanolides from Datura quercifolia</atitle><jtitle>Planta Medica International Open (Online)</jtitle><date>2020-05</date><risdate>2020</risdate><volume>7</volume><issue>2</issue><spage>e68</spage><epage>e72</epage><pages>e68-e72</pages><issn>2509-9264</issn><eissn>2509-6656</eissn><abstract>Abstract
Five withanolides identified as daturalactone
(1)
, withanicandrin
(2)
, withanolide B
(3)
, nicandrin B
(4)
, and
daturalactone 2
(5)
were isolated from the aerial parts (flowers,
leaves, and stems) of
Datura quercifolia
Kunth. Their structures were
determined by analysis of the IR, MS, 1D and 2D NMR spectra. All the
isolates were evaluated for their cytotoxic and antioxidant activities, as
well as for their capacity to inhibit the activity of the
acetylcholinesterase enzyme (AChE). As result, the five withanolides showed
weak cytotoxic and pro-oxidant activities, however, they displayed a
relevant inhibitory activity against AChE, as indicated by the
IC
50
values ranging from 1.51 to 12.11
µ
M. The
differences in AChE inhibition seem to be related to the functional group at
C-12.</abstract><cop>Stuttgart · New York</cop><pub>Georg Thieme Verlag KG</pub><doi>10.1055/a-1156-4229</doi><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Thieme Connect Journals Open Access |
| subjects | Original Papers |
| title | Antioxidant, Cytotoxic, and Acetylcholinesterase Inhibitory Activities of Withanolides from Datura quercifolia |
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