Antithrombotic effect of onion in streptozotocin-induced diabetic rat
In the present study, we investigated whether onion has antithrombotic effect in streptozotocin (STZ)-induced diabetic rats. In diabetic rats, serum thromboxane B2 (TXB2) level was elevated compared to that in normal, and this elevation in diabetes was significantly inhibited by treatment with onion...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2002-04, Vol.66 (4), p.453-458 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Jung, Yi-Sook Kim, Min Hwa Lee, Soo Hwan Baik, Eun Joo Park, Se Won Moon, Chang-Hyun |
| description | In the present study, we investigated whether onion has antithrombotic effect in streptozotocin (STZ)-induced diabetic rats. In diabetic rats, serum thromboxane B2 (TXB2) level was elevated compared to that in normal, and this elevation in diabetes was significantly inhibited by treatment with onion (0.5 g/ml/kg/day, i.p.) for 4 weeks. In normal rats, the serum TXB2 level remained unaltered after the treatment with onion. To investigate in vitro effect of onion, we examined its effect on TXB2 formation, platelet aggregation and arachidonic acid (AA)-release in platelets from diabetic and normal rats. Onion showed a significant inhibitory effect on collagen- or AA-induced TXB2 formation with greater potency in diabetic platelets than in normal. Similarly, more potent inhibitory effects of onion in diabetes were observed in collagen- or AA-induced platelet aggregation and collagen-induced AA release response. In conclusion, these results suggest that onion can produce more beneficial antithrombotic effect in diabetes. |
| doi_str_mv | 10.1054/plef.2002.0373 |
| format | Article |
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In diabetic rats, serum thromboxane B2 (TXB2) level was elevated compared to that in normal, and this elevation in diabetes was significantly inhibited by treatment with onion (0.5 g/ml/kg/day, i.p.) for 4 weeks. In normal rats, the serum TXB2 level remained unaltered after the treatment with onion. To investigate in vitro effect of onion, we examined its effect on TXB2 formation, platelet aggregation and arachidonic acid (AA)-release in platelets from diabetic and normal rats. Onion showed a significant inhibitory effect on collagen- or AA-induced TXB2 formation with greater potency in diabetic platelets than in normal. Similarly, more potent inhibitory effects of onion in diabetes were observed in collagen- or AA-induced platelet aggregation and collagen-induced AA release response. In conclusion, these results suggest that onion can produce more beneficial antithrombotic effect in diabetes.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1054/plef.2002.0373</identifier><identifier>PMID: 12054917</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Antithrombins - pharmacology ; Arachidonic Acids - metabolism ; Associated diseases and complications ; Biological and medical sciences ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes. Impaired glucose tolerance ; Dose-Response Relationship, Drug ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; L-Lactate Dehydrogenase - metabolism ; Male ; Medical sciences ; Onions ; Phytotherapy ; Plant Extracts - pharmacology ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; Rats ; Rats, Sprague-Dawley ; Streptozocin - pharmacology ; Thromboxane B2 - biosynthesis ; Thromboxane B2 - blood</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2002-04, Vol.66 (4), p.453-458</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Elsevier Science Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-87f9fe39ecfabe5812af5a9d64de6a59e6fa06dd26f76893b9428e8e58a597ff3</citedby><cites>FETCH-LOGICAL-c436t-87f9fe39ecfabe5812af5a9d64de6a59e6fa06dd26f76893b9428e8e58a597ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S095232780290373X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13741892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12054917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Yi-Sook</creatorcontrib><creatorcontrib>Kim, Min Hwa</creatorcontrib><creatorcontrib>Lee, Soo Hwan</creatorcontrib><creatorcontrib>Baik, Eun Joo</creatorcontrib><creatorcontrib>Park, Se Won</creatorcontrib><creatorcontrib>Moon, Chang-Hyun</creatorcontrib><title>Antithrombotic effect of onion in streptozotocin-induced diabetic rat</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>In the present study, we investigated whether onion has antithrombotic effect in streptozotocin (STZ)-induced diabetic rats. In diabetic rats, serum thromboxane B2 (TXB2) level was elevated compared to that in normal, and this elevation in diabetes was significantly inhibited by treatment with onion (0.5 g/ml/kg/day, i.p.) for 4 weeks. In normal rats, the serum TXB2 level remained unaltered after the treatment with onion. To investigate in vitro effect of onion, we examined its effect on TXB2 formation, platelet aggregation and arachidonic acid (AA)-release in platelets from diabetic and normal rats. Onion showed a significant inhibitory effect on collagen- or AA-induced TXB2 formation with greater potency in diabetic platelets than in normal. Similarly, more potent inhibitory effects of onion in diabetes were observed in collagen- or AA-induced platelet aggregation and collagen-induced AA release response. In conclusion, these results suggest that onion can produce more beneficial antithrombotic effect in diabetes.</description><subject>Animals</subject><subject>Antithrombins - pharmacology</subject><subject>Arachidonic Acids - metabolism</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Onions</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Streptozocin - pharmacology</subject><subject>Thromboxane B2 - biosynthesis</subject><subject>Thromboxane B2 - blood</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUQIMotla3LmU2LmfMYx7JshRfUHCj65BJbjDSJiVJBf16M7TQlass7jmXm4PQLcENwV37sNuAbSjGtMFsYGdoTjpGa8opO0dzLDpaMzrwGbpK6QsXjJD2Es0ILa4gwxw9Ln12-TOG7Riy0xVYCzpXwVbBu-Ar56uUI-xy-A05aOdr581eg6mMUyNMSlT5Gl1YtUlwc3wX6OPp8X31Uq_fnl9Xy3WtW9bnmg9WWGACtC1uxwlVtlPC9K2BXnUCeqtwbwzt7dBzwUbRUg68kGU4WMsWqDns1TGkFMHKXXRbFX8kwXLqIacecuohpx5FuDsIu_24BXPCjwEKcH8EVNJqY6Py2qUTx4aWcEELxw8clO99O4gyaQe-hHCxBJMmuP9u-AMEvn1U</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Jung, Yi-Sook</creator><creator>Kim, Min Hwa</creator><creator>Lee, Soo Hwan</creator><creator>Baik, Eun Joo</creator><creator>Park, Se Won</creator><creator>Moon, Chang-Hyun</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20020401</creationdate><title>Antithrombotic effect of onion in streptozotocin-induced diabetic rat</title><author>Jung, Yi-Sook ; Kim, Min Hwa ; Lee, Soo Hwan ; Baik, Eun Joo ; Park, Se Won ; Moon, Chang-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-87f9fe39ecfabe5812af5a9d64de6a59e6fa06dd26f76893b9428e8e58a597ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antithrombins - pharmacology</topic><topic>Arachidonic Acids - metabolism</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Onions</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Streptozocin - pharmacology</topic><topic>Thromboxane B2 - biosynthesis</topic><topic>Thromboxane B2 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Yi-Sook</creatorcontrib><creatorcontrib>Kim, Min Hwa</creatorcontrib><creatorcontrib>Lee, Soo Hwan</creatorcontrib><creatorcontrib>Baik, Eun Joo</creatorcontrib><creatorcontrib>Park, Se Won</creatorcontrib><creatorcontrib>Moon, Chang-Hyun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Yi-Sook</au><au>Kim, Min Hwa</au><au>Lee, Soo Hwan</au><au>Baik, Eun Joo</au><au>Park, Se Won</au><au>Moon, Chang-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antithrombotic effect of onion in streptozotocin-induced diabetic rat</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>66</volume><issue>4</issue><spage>453</spage><epage>458</epage><pages>453-458</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>In the present study, we investigated whether onion has antithrombotic effect in streptozotocin (STZ)-induced diabetic rats. In diabetic rats, serum thromboxane B2 (TXB2) level was elevated compared to that in normal, and this elevation in diabetes was significantly inhibited by treatment with onion (0.5 g/ml/kg/day, i.p.) for 4 weeks. In normal rats, the serum TXB2 level remained unaltered after the treatment with onion. To investigate in vitro effect of onion, we examined its effect on TXB2 formation, platelet aggregation and arachidonic acid (AA)-release in platelets from diabetic and normal rats. Onion showed a significant inhibitory effect on collagen- or AA-induced TXB2 formation with greater potency in diabetic platelets than in normal. Similarly, more potent inhibitory effects of onion in diabetes were observed in collagen- or AA-induced platelet aggregation and collagen-induced AA release response. In conclusion, these results suggest that onion can produce more beneficial antithrombotic effect in diabetes.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>12054917</pmid><doi>10.1054/plef.2002.0373</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antithrombins - pharmacology Arachidonic Acids - metabolism Associated diseases and complications Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Diabetes Mellitus, Experimental - chemically induced Diabetes. Impaired glucose tolerance Dose-Response Relationship, Drug Endocrine pancreas. Apud cells (diseases) Endocrinopathies L-Lactate Dehydrogenase - metabolism Male Medical sciences Onions Phytotherapy Plant Extracts - pharmacology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Rats Rats, Sprague-Dawley Streptozocin - pharmacology Thromboxane B2 - biosynthesis Thromboxane B2 - blood |
| title | Antithrombotic effect of onion in streptozotocin-induced diabetic rat |
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