Causes of Alzheimer’s disease: paracetamol (acetaminophen) today? Amphetamines tomorrow?
Phenacetin was implicated as a causative factor in Alzheimer’s disease (AD) in 1971. Although the chief metabolite, paracetamol, was earlier identified as responsible for its analgesic and antipyretic properties, a link with senile plaque formation does not appear to have been previously suspected....
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| Veröffentlicht in: | Medical hypotheses 2001-01, Vol.56 (1), p.121-123 |
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| container_title | Medical hypotheses |
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| creator | Jones, G.R.N. |
| description | Phenacetin was implicated as a causative factor in Alzheimer’s disease (AD) in 1971. Although the chief metabolite, paracetamol, was earlier identified as responsible for its analgesic and antipyretic properties, a link with senile plaque formation does not appear to have been previously suspected. In common with paracetamol, so-called recreational drugs (RDs) likewise stimulate free radical activity, and might therefore pose a similar danger in terms of causing AD later in life. The case for regarding the brain as an even more delicate and vulnerable structure than currently believed, at risk especially from substances untested in man but of proven neurotoxicity in rodents and non-human primates, needs to be taken more seriously than at present. |
| doi_str_mv | 10.1054/mehy.2000.1235 |
| format | Article |
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The case for regarding the brain as an even more delicate and vulnerable structure than currently believed, at risk especially from substances untested in man but of proven neurotoxicity in rodents and non-human primates, needs to be taken more seriously than at present.</description><identifier>ISSN: 0306-9877</identifier><identifier>EISSN: 1532-2777</identifier><identifier>DOI: 10.1054/mehy.2000.1235</identifier><identifier>PMID: 11133268</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Acetaminophen - adverse effects ; Aged ; Alzheimer Disease - chemically induced ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Free Radicals ; Humans ; Medical sciences ; Middle Aged ; N-Methyl-3,4-methylenedioxyamphetamine - adverse effects ; Pharmacology. 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The case for regarding the brain as an even more delicate and vulnerable structure than currently believed, at risk especially from substances untested in man but of proven neurotoxicity in rodents and non-human primates, needs to be taken more seriously than at present.</description><subject>Acetaminophen - adverse effects</subject><subject>Aged</subject><subject>Alzheimer Disease - chemically induced</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Free Radicals</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>N-Methyl-3,4-methylenedioxyamphetamine - adverse effects</subject><subject>Pharmacology. 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| ispartof | Medical hypotheses, 2001-01, Vol.56 (1), p.121-123 |
| issn | 0306-9877 1532-2777 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetaminophen - adverse effects Aged Alzheimer Disease - chemically induced Biological and medical sciences Drug toxicity and drugs side effects treatment Free Radicals Humans Medical sciences Middle Aged N-Methyl-3,4-methylenedioxyamphetamine - adverse effects Pharmacology. Drug treatments Toxicity: nervous system and muscle |
| title | Causes of Alzheimer’s disease: paracetamol (acetaminophen) today? Amphetamines tomorrow? |
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