Chronic inflammation and cancer: potential role of Bcl-2 gene family members as regulators of cellular antioxidant status

The incidence of cancer is increased in all gastrointestinal (GI) tissues as a result of chronic inflammation. These cancers may develop in cells that are selected for resistance to inflammatory products by virtue of overexpressing the antioxidant protein Bcl-2 or other Bcl-2 gene family members tha...

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Veröffentlicht in:	Medical hypotheses 1999-01, Vol.52 (1), p.27-30
Hauptverfasser:	Frommel, T.O., Zarling, E.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Apoptosis Biological and medical sciences DNA Damage Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Neoplasms - etiology Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - metabolism Gene Expression Genes, bcl-2 Humans Inflammation - complications Inflammation - genetics Inflammation - metabolism Medical sciences Models, Biological Multigene Family Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
Online-Zugang:	Volltext
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