Anthracycline drug targeting: cytoplasmic versus nuclear – a fork in the road

The anthracycline antibiotics doxorubicin (Adriamycin; DOX) and daunorubicin (DNR) continue to be essential components of first-line chemotherapy in the treatment of a variety of solid and hematopoietic tumors. The overall efficacies of DOX and DNR are, however, impeded by serious dose-limiting toxi...

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Veröffentlicht in:	Drug Resistance Updates 2001-06, Vol.4 (3), p.169-177
Hauptverfasser:	Lothstein, Leonard, Israel, Mervyn, Sweatman, Trevor W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Cell Nucleus - drug effects Cell Nucleus - enzymology Cell Nucleus - metabolism Cytoplasm - drug effects Cytoplasm - enzymology Cytoplasm - metabolism Drug Delivery Systems - methods Humans
Online-Zugang:	Volltext
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