Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?
Chorea is a rare side effect of anticonvulsants. We describe three patients who developed chorea secondary to anticonvulsant combination use. A mechanism to explain this finding is proposed. After identification of an index case with anticonvulsant-induced chorea, we reviewed the electronic data bas...
Gespeichert in:
| Veröffentlicht in: | Seizure (London, England) England), 2001-12, Vol.10 (8), p.596-599 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 599 |
|---|---|
| container_issue | 8 |
| container_start_page | 596 |
| container_title | Seizure (London, England) |
| container_volume | 10 |
| creator | Zaatreh, Megdad Tennison, Michael D'Cruz, O'Neill Beach, Robert L |
| description | Chorea is a rare side effect of anticonvulsants. We describe three patients who developed chorea secondary to anticonvulsant combination use. A mechanism to explain this finding is proposed.
After identification of an index case with anticonvulsant-induced chorea, we reviewed the electronic data base records for all patients with seizures followed in the epilepsy clinics at our university-based hospital for cases of dyskinesia associated with anticonvulsants. Two additional patients , one adult and one pediatric patient were identified.
Three patients developed chorea while receiving combination anticonvulsants. Two patients had transient chorea that resolved with withdrawal of one of the drugs. All three patients were using phenytoin and lamotrigine in combination when the chorea started, chorea improved with tapering one of the medications.
Polytherapy with certain anticonvulsants may predispose patients to drug-induced chorea. A particular increased risk was seen with combinations that have phenytoin and lamotrigine. This could be due to an additive or a synergistic effect on central dopaminergic pathways. |
| doi_str_mv | 10.1053/seiz.2001.0555 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1053_seiz_2001_0555</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1059131101905552</els_id><sourcerecordid>11792164</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-9f65b292cd4a7f4a8e1824b11b8c8e0617cf107712d56ee873f558f4eefc6383</originalsourceid><addsrcrecordid>eNp1kD1rwzAURUVpadK0a8fiP2BXz7JsuUsJoV8Q6JJdyNJToxLLQbID6a-vTQKdOr07nHt5HELugWZAOXuM6H6ynFLIKOf8gsyBszzNSyEux0x5nQIDmJGbGL8ppXUB7JrMAKo6h7KYk_XS9053_jDsovJ9TJ03g0aT6G0XUD0lKgndDhPbhWS_VaFVujNHr1qnExOGr8T5HoPSvev88y25smoX8e58F2Tz-rJZvafrz7eP1XKdaiZon9a25E1e59oUqrKFEggiLxqARmiBtIRKW6BVBbnhJaKomOVc2ALR6pIJtiDZaVaHLsaAVu6Da1U4SqBysiInK3KyIicrY-HhVNgPTYvmDz9rGAFxAnD8-uAwyKgd-tGDC6h7aTr33_Yv8_JyFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Zaatreh, Megdad ; Tennison, Michael ; D'Cruz, O'Neill ; Beach, Robert L</creator><creatorcontrib>Zaatreh, Megdad ; Tennison, Michael ; D'Cruz, O'Neill ; Beach, Robert L</creatorcontrib><description>Chorea is a rare side effect of anticonvulsants. We describe three patients who developed chorea secondary to anticonvulsant combination use. A mechanism to explain this finding is proposed.
After identification of an index case with anticonvulsant-induced chorea, we reviewed the electronic data base records for all patients with seizures followed in the epilepsy clinics at our university-based hospital for cases of dyskinesia associated with anticonvulsants. Two additional patients , one adult and one pediatric patient were identified.
Three patients developed chorea while receiving combination anticonvulsants. Two patients had transient chorea that resolved with withdrawal of one of the drugs. All three patients were using phenytoin and lamotrigine in combination when the chorea started, chorea improved with tapering one of the medications.
Polytherapy with certain anticonvulsants may predispose patients to drug-induced chorea. A particular increased risk was seen with combinations that have phenytoin and lamotrigine. This could be due to an additive or a synergistic effect on central dopaminergic pathways.</description><identifier>ISSN: 1059-1311</identifier><identifier>EISSN: 1532-2688</identifier><identifier>DOI: 10.1053/seiz.2001.0555</identifier><identifier>PMID: 11792164</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>anticonvulsant ; Anticonvulsants - adverse effects ; Anticonvulsants - blood ; Child, Preschool ; chorea ; Chorea - blood ; Chorea - chemically induced ; Drug Synergism ; Drug Therapy, Combination ; dyskinesia ; Dyskinesia, Drug-Induced - blood ; Dyskinesia, Drug-Induced - etiology ; Epilepsy - drug therapy ; Female ; Humans ; lamotrigine ; Male ; Middle Aged ; phenytoin ; Phenytoin - adverse effects ; Phenytoin - blood ; Syndrome ; Triazines - adverse effects ; Triazines - blood</subject><ispartof>Seizure (London, England), 2001-12, Vol.10 (8), p.596-599</ispartof><rights>2001 BEA Trading, Ltd</rights><rights>Copyright 2001 BEA Trading Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-9f65b292cd4a7f4a8e1824b11b8c8e0617cf107712d56ee873f558f4eefc6383</citedby><cites>FETCH-LOGICAL-c380t-9f65b292cd4a7f4a8e1824b11b8c8e0617cf107712d56ee873f558f4eefc6383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/seiz.2001.0555$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11792164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaatreh, Megdad</creatorcontrib><creatorcontrib>Tennison, Michael</creatorcontrib><creatorcontrib>D'Cruz, O'Neill</creatorcontrib><creatorcontrib>Beach, Robert L</creatorcontrib><title>Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?</title><title>Seizure (London, England)</title><addtitle>Seizure</addtitle><description>Chorea is a rare side effect of anticonvulsants. We describe three patients who developed chorea secondary to anticonvulsant combination use. A mechanism to explain this finding is proposed.
After identification of an index case with anticonvulsant-induced chorea, we reviewed the electronic data base records for all patients with seizures followed in the epilepsy clinics at our university-based hospital for cases of dyskinesia associated with anticonvulsants. Two additional patients , one adult and one pediatric patient were identified.
Three patients developed chorea while receiving combination anticonvulsants. Two patients had transient chorea that resolved with withdrawal of one of the drugs. All three patients were using phenytoin and lamotrigine in combination when the chorea started, chorea improved with tapering one of the medications.
Polytherapy with certain anticonvulsants may predispose patients to drug-induced chorea. A particular increased risk was seen with combinations that have phenytoin and lamotrigine. This could be due to an additive or a synergistic effect on central dopaminergic pathways.</description><subject>anticonvulsant</subject><subject>Anticonvulsants - adverse effects</subject><subject>Anticonvulsants - blood</subject><subject>Child, Preschool</subject><subject>chorea</subject><subject>Chorea - blood</subject><subject>Chorea - chemically induced</subject><subject>Drug Synergism</subject><subject>Drug Therapy, Combination</subject><subject>dyskinesia</subject><subject>Dyskinesia, Drug-Induced - blood</subject><subject>Dyskinesia, Drug-Induced - etiology</subject><subject>Epilepsy - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>lamotrigine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>phenytoin</subject><subject>Phenytoin - adverse effects</subject><subject>Phenytoin - blood</subject><subject>Syndrome</subject><subject>Triazines - adverse effects</subject><subject>Triazines - blood</subject><issn>1059-1311</issn><issn>1532-2688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1rwzAURUVpadK0a8fiP2BXz7JsuUsJoV8Q6JJdyNJToxLLQbID6a-vTQKdOr07nHt5HELugWZAOXuM6H6ynFLIKOf8gsyBszzNSyEux0x5nQIDmJGbGL8ppXUB7JrMAKo6h7KYk_XS9053_jDsovJ9TJ03g0aT6G0XUD0lKgndDhPbhWS_VaFVujNHr1qnExOGr8T5HoPSvev88y25smoX8e58F2Tz-rJZvafrz7eP1XKdaiZon9a25E1e59oUqrKFEggiLxqARmiBtIRKW6BVBbnhJaKomOVc2ALR6pIJtiDZaVaHLsaAVu6Da1U4SqBysiInK3KyIicrY-HhVNgPTYvmDz9rGAFxAnD8-uAwyKgd-tGDC6h7aTr33_Yv8_JyFA</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Zaatreh, Megdad</creator><creator>Tennison, Michael</creator><creator>D'Cruz, O'Neill</creator><creator>Beach, Robert L</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20011201</creationdate><title>Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?</title><author>Zaatreh, Megdad ; Tennison, Michael ; D'Cruz, O'Neill ; Beach, Robert L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-9f65b292cd4a7f4a8e1824b11b8c8e0617cf107712d56ee873f558f4eefc6383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>anticonvulsant</topic><topic>Anticonvulsants - adverse effects</topic><topic>Anticonvulsants - blood</topic><topic>Child, Preschool</topic><topic>chorea</topic><topic>Chorea - blood</topic><topic>Chorea - chemically induced</topic><topic>Drug Synergism</topic><topic>Drug Therapy, Combination</topic><topic>dyskinesia</topic><topic>Dyskinesia, Drug-Induced - blood</topic><topic>Dyskinesia, Drug-Induced - etiology</topic><topic>Epilepsy - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>lamotrigine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>phenytoin</topic><topic>Phenytoin - adverse effects</topic><topic>Phenytoin - blood</topic><topic>Syndrome</topic><topic>Triazines - adverse effects</topic><topic>Triazines - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaatreh, Megdad</creatorcontrib><creatorcontrib>Tennison, Michael</creatorcontrib><creatorcontrib>D'Cruz, O'Neill</creatorcontrib><creatorcontrib>Beach, Robert L</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Seizure (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaatreh, Megdad</au><au>Tennison, Michael</au><au>D'Cruz, O'Neill</au><au>Beach, Robert L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?</atitle><jtitle>Seizure (London, England)</jtitle><addtitle>Seizure</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>10</volume><issue>8</issue><spage>596</spage><epage>599</epage><pages>596-599</pages><issn>1059-1311</issn><eissn>1532-2688</eissn><abstract>Chorea is a rare side effect of anticonvulsants. We describe three patients who developed chorea secondary to anticonvulsant combination use. A mechanism to explain this finding is proposed.
After identification of an index case with anticonvulsant-induced chorea, we reviewed the electronic data base records for all patients with seizures followed in the epilepsy clinics at our university-based hospital for cases of dyskinesia associated with anticonvulsants. Two additional patients , one adult and one pediatric patient were identified.
Three patients developed chorea while receiving combination anticonvulsants. Two patients had transient chorea that resolved with withdrawal of one of the drugs. All three patients were using phenytoin and lamotrigine in combination when the chorea started, chorea improved with tapering one of the medications.
Polytherapy with certain anticonvulsants may predispose patients to drug-induced chorea. A particular increased risk was seen with combinations that have phenytoin and lamotrigine. This could be due to an additive or a synergistic effect on central dopaminergic pathways.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11792164</pmid><doi>10.1053/seiz.2001.0555</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1059-1311 |
| ispartof | Seizure (London, England), 2001-12, Vol.10 (8), p.596-599 |
| issn | 1059-1311 1532-2688 |
| language | eng |
| recordid | cdi_crossref_primary_10_1053_seiz_2001_0555 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | anticonvulsant Anticonvulsants - adverse effects Anticonvulsants - blood Child, Preschool chorea Chorea - blood Chorea - chemically induced Drug Synergism Drug Therapy, Combination dyskinesia Dyskinesia, Drug-Induced - blood Dyskinesia, Drug-Induced - etiology Epilepsy - drug therapy Female Humans lamotrigine Male Middle Aged phenytoin Phenytoin - adverse effects Phenytoin - blood Syndrome Triazines - adverse effects Triazines - blood |
| title | Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T21%3A17%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anticonvulsants-induced%20chorea:%20a%20role%20for%20pharmacodynamic%20drug%20interaction?&rft.jtitle=Seizure%20(London,%20England)&rft.au=Zaatreh,%20Megdad&rft.date=2001-12-01&rft.volume=10&rft.issue=8&rft.spage=596&rft.epage=599&rft.pages=596-599&rft.issn=1059-1311&rft.eissn=1532-2688&rft_id=info:doi/10.1053/seiz.2001.0555&rft_dat=%3Cpubmed_cross%3E11792164%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/11792164&rft_els_id=S1059131101905552&rfr_iscdi=true |