A case of fever following antiepileptic treatment
A 23-year-old female patient treated with 900 mg oxcarbazepine for complex partial seizures is presented. Good seizure control and slight fever were noted a few weeks after drug administration. Reduction of oxcarbazepine and replacement with valproate resulted in a transient normothermia. Because of...
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| Veröffentlicht in: | Seizure (London, England) England), 1999-05, Vol.8 (3), p.187-189 |
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| container_title | Seizure (London, England) |
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| creator | Gatzonis, S. Laiaki, A. Chioni, A. Siafakas, A. Zournas, Ch Mantouvalos, V. |
| description | A 23-year-old female patient treated with 900 mg oxcarbazepine for complex partial seizures is presented. Good seizure control and slight fever were noted a few weeks after drug administration. Reduction of oxcarbazepine and replacement with valproate resulted in a transient normothermia. Because of fever reappearance, vigabatrin was added and valproate was gradually reduced. Seizures reappeared, but the body temperature fell below 37∘C. Substitution of valproate for lamotrigine resulted in seizure control but abnormal body temperature (37– 37.6∘C) was noted again. Repeated hospital admission for clinical and laboratory investigation before any change of treatment revealed no other abnormal findings. The patient’s abnormal temperature possibly reflects a derangement of high-level temperature control. |
| doi_str_mv | 10.1053/seiz.1998.0262 |
| format | Article |
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Good seizure control and slight fever were noted a few weeks after drug administration. Reduction of oxcarbazepine and replacement with valproate resulted in a transient normothermia. Because of fever reappearance, vigabatrin was added and valproate was gradually reduced. Seizures reappeared, but the body temperature fell below 37∘C. Substitution of valproate for lamotrigine resulted in seizure control but abnormal body temperature (37– 37.6∘C) was noted again. Repeated hospital admission for clinical and laboratory investigation before any change of treatment revealed no other abnormal findings. 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Good seizure control and slight fever were noted a few weeks after drug administration. Reduction of oxcarbazepine and replacement with valproate resulted in a transient normothermia. Because of fever reappearance, vigabatrin was added and valproate was gradually reduced. Seizures reappeared, but the body temperature fell below 37∘C. Substitution of valproate for lamotrigine resulted in seizure control but abnormal body temperature (37– 37.6∘C) was noted again. Repeated hospital admission for clinical and laboratory investigation before any change of treatment revealed no other abnormal findings. The patient’s abnormal temperature possibly reflects a derangement of high-level temperature control.</description><subject>Adult</subject><subject>Anticonvulsants - adverse effects</subject><subject>antiepileptic drugs</subject><subject>Body Temperature Regulation - drug effects</subject><subject>Carbamazepine - adverse effects</subject><subject>Carbamazepine - analogs & derivatives</subject><subject>Drug Therapy, Combination</subject><subject>epilepsy</subject><subject>Epilepsy, Complex Partial - drug therapy</subject><subject>Female</subject><subject>fever</subject><subject>Fever of Unknown Origin - chemically induced</subject><subject>gamma-Aminobutyric Acid - adverse effects</subject><subject>gamma-Aminobutyric Acid - analogs & derivatives</subject><subject>Humans</subject><subject>lamotrigine</subject><subject>oxcarbazepine</subject><subject>side-effects</subject><subject>Triazines - adverse effects</subject><subject>valproate</subject><subject>Valproic Acid - adverse effects</subject><subject>Vigabatrin</subject><issn>1059-1311</issn><issn>1532-2688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1j7tOxDAQRS0EYmGhpUT5gYTxK9jlasVLWokGaiuxx8gom0S2WQRfT6JQ0FDNLc69mkPIFYWKguQ3CcN3RbVWFbCaHZEzKjkrWa3U8ZRB6pJySlfkPKV3ANCC8lOyosBlzRWcEbopbJOwGHzh8YCx8EPXDZ-hfyuaPgccQ4djDrbIEZu8xz5fkBPfdAkvf--avN7fvWwfy93zw9N2syst5zKXnLWaa28pdUzUt6BASOeFsLZ22ECtnGStYqqdsm4t1wK8towypwT3qPmaVMuujUNKEb0ZY9g38ctQMLO7md3N7G5m96lwvRTGj3aP7g--yE6AWgCc3j4EjCbZgL1FFyLabNwQ_tv-ARZ9Z7U</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>Gatzonis, S.</creator><creator>Laiaki, A.</creator><creator>Chioni, A.</creator><creator>Siafakas, A.</creator><creator>Zournas, Ch</creator><creator>Mantouvalos, V.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19990501</creationdate><title>A case of fever following antiepileptic treatment</title><author>Gatzonis, S. ; Laiaki, A. ; Chioni, A. ; Siafakas, A. ; Zournas, Ch ; Mantouvalos, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-32b939fc11d246708045df44cc6dea068d52b828ba069bc3940f9c212d843fe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Anticonvulsants - adverse effects</topic><topic>antiepileptic drugs</topic><topic>Body Temperature Regulation - drug effects</topic><topic>Carbamazepine - adverse effects</topic><topic>Carbamazepine - analogs & derivatives</topic><topic>Drug Therapy, Combination</topic><topic>epilepsy</topic><topic>Epilepsy, Complex Partial - drug therapy</topic><topic>Female</topic><topic>fever</topic><topic>Fever of Unknown Origin - chemically induced</topic><topic>gamma-Aminobutyric Acid - adverse effects</topic><topic>gamma-Aminobutyric Acid - analogs & derivatives</topic><topic>Humans</topic><topic>lamotrigine</topic><topic>oxcarbazepine</topic><topic>side-effects</topic><topic>Triazines - adverse effects</topic><topic>valproate</topic><topic>Valproic Acid - adverse effects</topic><topic>Vigabatrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gatzonis, S.</creatorcontrib><creatorcontrib>Laiaki, A.</creatorcontrib><creatorcontrib>Chioni, A.</creatorcontrib><creatorcontrib>Siafakas, A.</creatorcontrib><creatorcontrib>Zournas, Ch</creatorcontrib><creatorcontrib>Mantouvalos, V.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Seizure (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gatzonis, S.</au><au>Laiaki, A.</au><au>Chioni, A.</au><au>Siafakas, A.</au><au>Zournas, Ch</au><au>Mantouvalos, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of fever following antiepileptic treatment</atitle><jtitle>Seizure (London, England)</jtitle><addtitle>Seizure</addtitle><date>1999-05-01</date><risdate>1999</risdate><volume>8</volume><issue>3</issue><spage>187</spage><epage>189</epage><pages>187-189</pages><issn>1059-1311</issn><eissn>1532-2688</eissn><abstract>A 23-year-old female patient treated with 900 mg oxcarbazepine for complex partial seizures is presented. Good seizure control and slight fever were noted a few weeks after drug administration. Reduction of oxcarbazepine and replacement with valproate resulted in a transient normothermia. Because of fever reappearance, vigabatrin was added and valproate was gradually reduced. Seizures reappeared, but the body temperature fell below 37∘C. Substitution of valproate for lamotrigine resulted in seizure control but abnormal body temperature (37– 37.6∘C) was noted again. Repeated hospital admission for clinical and laboratory investigation before any change of treatment revealed no other abnormal findings. The patient’s abnormal temperature possibly reflects a derangement of high-level temperature control.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>10356380</pmid><doi>10.1053/seiz.1998.0262</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Seizure (London, England), 1999-05, Vol.8 (3), p.187-189 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Anticonvulsants - adverse effects antiepileptic drugs Body Temperature Regulation - drug effects Carbamazepine - adverse effects Carbamazepine - analogs & derivatives Drug Therapy, Combination epilepsy Epilepsy, Complex Partial - drug therapy Female fever Fever of Unknown Origin - chemically induced gamma-Aminobutyric Acid - adverse effects gamma-Aminobutyric Acid - analogs & derivatives Humans lamotrigine oxcarbazepine side-effects Triazines - adverse effects valproate Valproic Acid - adverse effects Vigabatrin |
| title | A case of fever following antiepileptic treatment |
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