Hydrogen peroxide mediates vascular cell adhesion molecule-1 expression from interleukin-18–activated hepatic sinusoidal endothelium: Implications for circulating cancer cell arrest in the murine liver

The mechanism of intrasinusoidal arrest of circulating cancer cells, which is a critical step in liver metastasis, appears to be facilitated by tumor-derived proinflammatory factors that increase sinusoidal cell adhesion receptors for cancer cells. However, how this prometastatic microenvironment is...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2001-08, Vol.34 (2), p.298-310
Hauptverfasser:	Mendoza, Lorea, Carrascal, Teresa, De Luca, Marco, Fuentes, Angela M., Salado, Clarisa, Blanco, Jerónimo, Vidal-Vanaclocha, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Adhesion - physiology Cell Cycle Cells, Cultured Culture Media - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Gastroenterology. Liver. Pancreas. Abdomen Hydrogen Peroxide - metabolism Inflammation Mediators - physiology Interleukin-18 - pharmacology Liver Circulation - drug effects Liver Neoplasms - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Melanoma - metabolism Melanoma - pathology Melanoma - physiopathology Melanoma - secondary Mice Mice, Inbred C57BL Neoplasm Transplantation Oxidants - metabolism Tumors Up-Regulation Vascular Cell Adhesion Molecule-1 - metabolism
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