Overexpression of γ-glutamylcysteine synthetase in human malignant mesothelioma

Mesothelioma is a fatal tumor resistant to all treatment modalities for reasons that are still unresolved. Glutathione (GSH)-associated pathways are induced by oxidants and cytotoxic drugs, and they are also involved in the progression and resistance of some tumor cells in vitro. The rate-limiting e...

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Veröffentlicht in:	Human pathology 2002-07, Vol.33 (7), p.748-755
Hauptverfasser:	Järvinen, Kristiina, Soini, Ylermi, Kahlos, Katriina, Kinnula, Vuokko L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents antioxidant Apoptosis - drug effects ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biological and medical sciences buthionine sulfoximine Buthionine Sulfoximine - pharmacology Cell Division Cell Survival - drug effects Chemotherapy cisplatin Cisplatin - pharmacology Dipeptides - antagonists & inhibitors Dipeptides - metabolism Dose-Response Relationship, Drug Drug Synergism Enzyme Inhibitors - pharmacology Female Fluorescent Antibody Technique, Indirect glutathione Humans Immunoenzyme Techniques In Situ Nick-End Labeling Male Medical sciences Membrane Transport Proteins Mesothelioma - enzymology Mesothelioma - pathology multidrug Multidrug Resistance-Associated Proteins - metabolism Pharmacology. Drug treatments Pleura - enzymology Pleural Neoplasms - enzymology Pleural Neoplasms - pathology Pneumology resistance protein Tumor Cells, Cultured Tumors of the respiratory system and mediastinum
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