Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus

Background & Aims:To explore mechanisms whereby acid reflux might contribute to carcinogenesis in Barrett's esophagus (BE) we studied: (1) the effects of acid on the mitogen-activated protein kinase (MAPK) pathways, cell proliferation, and apoptosis in a Barrett's adenocarcinoma cell l...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2002-02, Vol.122 (2), p.299-307
Hauptverfasser:	Souza, Rhonda F., Shewmake, Kenneth, Terada, Lance S., Spechler, Stuart Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Apoptosis - drug effects Barrett Esophagus - metabolism Barrett Esophagus - pathology Biological and medical sciences Biopsy Cell Count Cell Division - drug effects Cell Survival - drug effects Enzyme Activation - drug effects Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Gastroenterology. Liver. Pancreas. Abdomen Humans Hydrochloric Acid - pharmacology JNK Mitogen-Activated Protein Kinases MAP Kinase Kinase 4 MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medical sciences Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism Mucous Membrane - enzymology Mucous Membrane - pathology Other diseases. Semiology p38 Mitogen-Activated Protein Kinases Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - enzymology
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