Interleukin 16 Is Up-regulated in Crohn's disease and participates in TNBS colitis in mice

Background & Aims: Interleukin (IL)-16 is a T lymphocyte-derived cytokine that uses CD4 as its receptor and hence selectively recruits CD4-bearing cells. Infiltrating CD4+ T cells are a feature of Crohn's disease; however, the role of IL-16 in intestinal inflammation is unknown. The aim of...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2000-10, Vol.119 (4), p.972-982
Hauptverfasser:	Keates, Andrew C., Castagliuolo, Ignazio, Cruickshank, William W., Qiu, Bosheng, Arseneau, Kristen O., Grazer, William, Kellya, Ciarán P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Biological and medical sciences Colitis - chemically induced Colitis - genetics Colitis - immunology Colitis - therapy Colon - immunology Colon - pathology Crohn Disease - genetics Crohn Disease - immunology Crohn Disease - pathology Disease Models, Animal Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation Humans Interleukin-16 - analysis Interleukin-16 - genetics Interleukin-16 - immunology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Other diseases. Semiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription, Genetic Trinitrobenzenesulfonic Acid
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