Low-dose methotrexate is ineffective in primary biliary cirrhosis: Long-term results of a placebo-controlled trial

Background & Aims: New treatments for primary biliary cirrhosis (PBC) need to be evaluated. We conducted a single-center double-blind, randomized trial of methotrexate, 7.5 mg/wk (n = 30), vs. placebo (n = 30) for up to 6 years in PBC. Methods: Methods included three monthly symptom assessment a...

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