Intravenous Itasetron: Establishing the Effective Dose Range for the Prophylactic Control of Acute Emesis in Cancer Patients Undergoing High-Dose Cisplatin Chemotherapy

Nausea and vomiting induced by chemotherapy are a major cause of distress to patients and reduce compliance with potentially beneficial treatment. Itasetron hydrochloride is a new 5-hydroxytryptamine3 (5-HT3) antagonist with potent antiemetic properties. It is more potent than ondansetron in animal...

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Veröffentlicht in:	Clinical oncology (Royal College of Radiologists (Great Britain)) 1999-01, Vol.11 (2), p.99-104
Hauptverfasser:	Patoia, L., Del Favero, A., Giglietti, A., Malacarne, P., Donati, D., Indelli, M., Bensi, G., Palladino, M.A., Cigarini, P., Kempe, R., Voigt, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Aged Antiemetics - administration & dosage Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Benzimidazoles - administration & dosage Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Cisplatin Cisplatin - administration & dosage Cisplatin - adverse effects Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Emesis Female Humans Injections, Intravenous Itasetron Male Medical sciences Middle Aged Pharmacology. Drug treatments Severity of Illness Index Toxicity: digestive system Treatment Outcome Vomiting - chemically induced Vomiting - prevention & control
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