Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12

FK506-binding protein (FKBP12) is highly expressed in neuronal tissue, where it is proposed to localize calcineurin to intracellular calcium-release channels, ryanodine receptors and Ins(1,4,5)P3 receptors (InsP3Rs). The effects of FKBP12 on ryanodine receptors have been well characterized but the n...

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Veröffentlicht in:Biochemical journal 2002-01, Vol.361 (2), p.401-407
Hauptverfasser: DARGAN, Sheila L., LEA, Edward J. A., DAWSON, Alan P.
Format: Artikel
Sprache:eng
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