Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor

Urokinase (uPA) has the striking ability to cleave its receptor, uPAR, thereby inactivating the binding potential of this molecule. Here we demonstrate that the glycosylphosphatidylinositol (GPI) anchor of uPAR, which is attached to the third domain, is an important determinant in governing this rea...

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Veröffentlicht in:	Biochemical journal 2001-09, Vol.358 (3), p.673-679
Hauptverfasser:	HØYER-HANSEN, Gunilla, PESSARA, Ulrich, HOLM, Arne, PASS, Jesper, WEIDLE, Ulrich, DANØ, Keld, BEHRENDT, Niels
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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