Transmembrane-truncated αvβ3 integrin retains high affinity for ligand binding: evidence for an ‘inside-out’ suppressor?

The molecular mechanisms of αvβ3 integrin affinity regulation have important biological implications in tumour development, wound repair and angiogenesis. We expressed, purified and characterized recombinant forms of human αvβ3 (r-αvβ3) and compared the activation state of these with αvβ3 in its cel...

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Veröffentlicht in:	Biochemical journal 1998-03, Vol.330 (2), p.861-869
Hauptverfasser:	MEHTA, J. Raj, DIEFENBACH, Beate, BROWN, Alex, CULLEN, Eilish, JONCZYK, Alfred, GÜSSOW, Detlef, LUCKENBACH, G. Albrecht, GOODMAN, L. Simon
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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