Involvement of interleukin-1β mediated nuclear factor κB signalling pathways to down-regulate prostate-specific antigen and cell proliferation in LNCaP prostate cancer cells
Involvement of NF‐κB (nuclear factor κB) mediated by IL‐1β (interleukin‐1β) on cell proliferation and PSA (prostate‐specific antigen) production of LNCaP prostate cell lines and the possible cross‐talk with Akt (also known as protein kinase B) signalling pathway has been investigated. NF‐κB and Akt...
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| Veröffentlicht in: | Cell biology international 2012-05, Vol.36 (5), p.449-454 |
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| creator | Bouraoui, Yosra Rais, Nawfel Ben Culig, Zoran Oueslati, Ridha |
| description | Involvement of NF‐κB (nuclear factor κB) mediated by IL‐1β (interleukin‐1β) on cell proliferation and PSA (prostate‐specific antigen) production of LNCaP prostate cell lines and the possible cross‐talk with Akt (also known as protein kinase B) signalling pathway has been investigated. NF‐κB and Akt were analysed by Western blotting from LNCaP cells treated by IL‐1β before proliferation and PSA production were measured. IL‐1β inhibited proliferation and decreased PSA production. The Akt pathway was not sensitive, whereas NF‐κB phosphorylation occurred as a result of treatment. PSA production and proliferation of LNCaP cells were down‐regulated by NF‐κB mediated by IL‐1β promoting anti‐apoptotic signalling and co‐suppressor factors of PSA expression. IL‐1β through NF‐κB activation provides a rationale for therapeutic approaches in the anticancer treatment of prostate. |
| doi_str_mv | 10.1042/CBI20100922 |
| format | Article |
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NF‐κB and Akt were analysed by Western blotting from LNCaP cells treated by IL‐1β before proliferation and PSA production were measured. IL‐1β inhibited proliferation and decreased PSA production. The Akt pathway was not sensitive, whereas NF‐κB phosphorylation occurred as a result of treatment. PSA production and proliferation of LNCaP cells were down‐regulated by NF‐κB mediated by IL‐1β promoting anti‐apoptotic signalling and co‐suppressor factors of PSA expression. 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NF‐κB and Akt were analysed by Western blotting from LNCaP cells treated by IL‐1β before proliferation and PSA production were measured. IL‐1β inhibited proliferation and decreased PSA production. The Akt pathway was not sensitive, whereas NF‐κB phosphorylation occurred as a result of treatment. PSA production and proliferation of LNCaP cells were down‐regulated by NF‐κB mediated by IL‐1β promoting anti‐apoptotic signalling and co‐suppressor factors of PSA expression. IL‐1β through NF‐κB activation provides a rationale for therapeutic approaches in the anticancer treatment of prostate.</description><subject>Apoptosis</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Down-Regulation</subject><subject>Humans</subject><subject>Interleukin-1beta - metabolism</subject><subject>Interleukin-1beta - pharmacology</subject><subject>interleukin-1β (IL-1β)</subject><subject>Male</subject><subject>NF-kappa B - metabolism</subject><subject>nuclear factor κB (NF-κB)</subject><subject>Phosphorylation</subject><subject>prostate-specific antigen (PSA)</subject><subject>Prostate-Specific Antigen - metabolism</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Signal Transduction</subject><subject>signalling pathways</subject><issn>1065-6995</issn><issn>1095-8355</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2O0zAUhSMEYn5gxR55jzLYTuzYS6aCoagKswANYhPdOjfFjOtEtjulT4XEkoeYZ8KlULFidc_i-46uTlE8Y_SC0Zq_nF3OOWWUas4fFKeMalGqSoiH-yxFKbUWJ8VZjF8pZaxW8nFxwjmjVSXkafF97u9Gd4dr9ImMA7E-YXC4ubW-ZPc_yBp7Cwl74jfGIQQygEljIPc_L0m0Kw_OWb8iE6QvW9hFkkbSj1tfBlxtXBbJFMaYcijjhMYO1hDwya7Q59sTg87tEWcHDJDs6PMHZNHO4PpoEgPeYPjNxifFowFcxKd_7nnx8c3rD7O35eL91Xz2alGaSipRsoYvFTd6qATCUjV9zYXmvZJSDFSovhemlwpB11wJsUSJAKiAaiMb1QiozosXh16Tv4gBh24Kdg1h1zHa7Wfv_pk9088P9LRZ5sWO7N-dM8AOwNY63P2va59bzrTITnlwbEz47ehAuO1kUzWiu2mvunc31_Wn9nPbqeoXpXSgiQ</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Bouraoui, Yosra</creator><creator>Rais, Nawfel Ben</creator><creator>Culig, Zoran</creator><creator>Oueslati, Ridha</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201205</creationdate><title>Involvement of interleukin-1β mediated nuclear factor κB signalling pathways to down-regulate prostate-specific antigen and cell proliferation in LNCaP prostate cancer cells</title><author>Bouraoui, Yosra ; Rais, Nawfel Ben ; Culig, Zoran ; Oueslati, Ridha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3685-172b82c9f35eab87d42592d8665f058dd5cd68ea942855be6eaae8a09c67875a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Apoptosis</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Down-Regulation</topic><topic>Humans</topic><topic>Interleukin-1beta - metabolism</topic><topic>Interleukin-1beta - pharmacology</topic><topic>interleukin-1β (IL-1β)</topic><topic>Male</topic><topic>NF-kappa B - metabolism</topic><topic>nuclear factor κB (NF-κB)</topic><topic>Phosphorylation</topic><topic>prostate-specific antigen (PSA)</topic><topic>Prostate-Specific Antigen - metabolism</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Signal Transduction</topic><topic>signalling pathways</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouraoui, Yosra</creatorcontrib><creatorcontrib>Rais, Nawfel Ben</creatorcontrib><creatorcontrib>Culig, Zoran</creatorcontrib><creatorcontrib>Oueslati, Ridha</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cell biology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouraoui, Yosra</au><au>Rais, Nawfel Ben</au><au>Culig, Zoran</au><au>Oueslati, Ridha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of interleukin-1β mediated nuclear factor κB signalling pathways to down-regulate prostate-specific antigen and cell proliferation in LNCaP prostate cancer cells</atitle><jtitle>Cell biology international</jtitle><addtitle>Cell Biol Int</addtitle><date>2012-05</date><risdate>2012</risdate><volume>36</volume><issue>5</issue><spage>449</spage><epage>454</epage><pages>449-454</pages><issn>1065-6995</issn><eissn>1095-8355</eissn><abstract>Involvement of NF‐κB (nuclear factor κB) mediated by IL‐1β (interleukin‐1β) on cell proliferation and PSA (prostate‐specific antigen) production of LNCaP prostate cell lines and the possible cross‐talk with Akt (also known as protein kinase B) signalling pathway has been investigated. NF‐κB and Akt were analysed by Western blotting from LNCaP cells treated by IL‐1β before proliferation and PSA production were measured. IL‐1β inhibited proliferation and decreased PSA production. The Akt pathway was not sensitive, whereas NF‐κB phosphorylation occurred as a result of treatment. PSA production and proliferation of LNCaP cells were down‐regulated by NF‐κB mediated by IL‐1β promoting anti‐apoptotic signalling and co‐suppressor factors of PSA expression. IL‐1β through NF‐κB activation provides a rationale for therapeutic approaches in the anticancer treatment of prostate.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22103356</pmid><doi>10.1042/CBI20100922</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cell biology international, 2012-05, Vol.36 (5), p.449-454 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Apoptosis Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Down-Regulation Humans Interleukin-1beta - metabolism Interleukin-1beta - pharmacology interleukin-1β (IL-1β) Male NF-kappa B - metabolism nuclear factor κB (NF-κB) Phosphorylation prostate-specific antigen (PSA) Prostate-Specific Antigen - metabolism Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction signalling pathways |
| title | Involvement of interleukin-1β mediated nuclear factor κB signalling pathways to down-regulate prostate-specific antigen and cell proliferation in LNCaP prostate cancer cells |
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