Erianin suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK MAPK signaling pathways

Hepatocellular carcinoma (HCC) is the dominant pathological type of primary liver cancer and no effective methods are available for its treatment. Erianin is a natural product extracted from Dendrobium, which possesses multiple pharmacological activities, including antioxidative and antitumor activi...

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Veröffentlicht in:	Bioscience reports 2020-07, Vol.40 (7)
Hauptverfasser:	Yang, Liang, Hu, Yue, Zhou, Guanbao, Chen, Qi, Song, Zhenshun
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Bibenzyls - pharmacology Bibenzyls - therapeutic use Cancer Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Proliferation - drug effects Down-Regulation - drug effects Drug Screening Assays, Antitumor Gene Expression Regulation, Neoplastic - drug effects Hep G2 Cells Humans Liver Neoplasms - drug therapy Liver Neoplasms - pathology MAP Kinase Signaling System - drug effects Neoplasm Invasiveness - genetics Neoplasm Invasiveness - prevention & control Phenol - pharmacology Phenol - therapeutic use Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism
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