A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288

DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene; however, our knowledge of DYRK1B has been limited by the lack of selective inhibitors. In the present study we describe AZ191, a potent small molecule inhibitor that selecti...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical journal 2014-01, Vol.457 (1), p.43-56
Hauptverfasser:	Ashford, Anne L., Oxley, David, Kettle, Jason, Hudson, Kevin, Guichard, Sylvie, Cook, Simon J., Lochhead, Pamela A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!