Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity

2SC [S-(2-succino)-cysteine] is a chemical modification formed by a Michael addition reaction of fumarate with cysteine residues in proteins. Formation of 2SC, termed 'succination' of proteins, increases in adipocytes grown in high-glucose medium and in adipose tissues of Type 2 diabetic m...

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Veröffentlicht in:	Biochemical journal 2012-07, Vol.445 (2), p.247-254
Hauptverfasser:	Frizzell, Norma, Thomas, Sonia A, Carson, James A, Baynes, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipocytes - drug effects Adipocytes - metabolism Adipocytes - pathology Animals Blotting, Western Cell Survival Citric Acid Cycle Electrophoresis, Gel, Two-Dimensional Fumarates - metabolism Glucose - toxicity Hypoxia Malates - metabolism Membrane Potential, Mitochondrial Mice Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Oxidative Phosphorylation Oxidative Phosphorylation Coupling Factors Oxidative Stress Succinic Acid - metabolism Sweetening Agents - toxicity
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