Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes

Aβ (amyloid-β peptide) assembles to form amyloid fibres that accumulate in senile plaques associated with AD (Alzheimer's disease). The major constituent, a 42-residue Aβ, has the propensity to assemble and form soluble and potentially cytotoxic oligomers, as well as ordered stable amyloid fibr...

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Veröffentlicht in:	Biochemical journal 2011-10, Vol.439 (1), p.67-77
Hauptverfasser:	Williams, Thomas L, Johnson, Benjamin R G, Urbanc, Brigita, Jenkins, A Toby A, Connell, Simon D A, Serpell, Louise C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - chemistry Lipid Bilayers - chemistry Microscopy, Atomic Force Microscopy, Electron, Transmission Protein Binding Spectrometry, Fluorescence
Online-Zugang:	Volltext
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