Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1

Scorpions are insensitive to their own venoms, which contain various neurotoxins specific for mammalian or insect ion channels, whose molecular mechanism remains unsolved. Using MmKv1, a potassium channel identified from the genome of the scorpion Mesobuthus martensii, channel kinetic experiments sh...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical journal 2016-05, Vol.473 (9), p.1257-1266
Hauptverfasser:	Zhang, Chuangeng, Xie, Zili, Li, Xinxin, Chen, Jing, Feng, Jing, Lang, Yange, Yang, Weishan, Li, Wenxin, Chen, Zongyun, Yao, Jing, Cao, Zhijian, Wu, Yingliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Arthropod Proteins - genetics Arthropod Proteins - metabolism Drug Resistance - physiology Humans Kv1.3 Potassium Channel - genetics Kv1.3 Potassium Channel - metabolism Mutation, Missense Scorpion Venoms - pharmacology Scorpions - genetics Scorpions - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!