Quantitative and real-time effects of carbon quantum dots on single living HeLa cell membrane permeability
The interaction between carbon quantum dots (CQDs) and a single living cell was explored in real time. Here, we provide the quantitative data on the permeability of the HeLa cell membrane in the presence of CQDs with different surface functional groups (CQDs terminated with -OH/-COOH (CQD-OH), -PEG...
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| Veröffentlicht in: | Nanoscale 2014-05, Vol.6 (1), p.5116-512 |
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| creator | Kong, Weiqian Liu, Juan Liu, Ruihua Li, Hao Liu, Yang Huang, Hui Li, Kunyang Liu, Jian Lee, Shuit-Tong Kang, Zhenhui |
| description | The interaction between carbon quantum dots (CQDs) and a single living cell was explored in real time. Here, we provide the quantitative data on the permeability of the HeLa cell membrane in the presence of CQDs with different surface functional groups (CQDs terminated with -OH/-COOH (CQD-OH), -PEG (CQD-PEG), and -NH
2
(CQD-NH
2
)). Although these CQDs have very low toxicity towards HeLa cells, they still increase the cell membrane permeability by 8%, 13%, and 19% for CQD-PEG, CQD-OH, and CQD-NH
2
, respectively, and this kind of permeability was irreversible. These observations are valuable for promoting the bio-applications of carbon nanostructures in living systems.
Low toxicity and biocompatible CQDs with different surfaces show different effects on the increasing cell membrane permeability. |
| doi_str_mv | 10.1039/c3nr06590a |
| format | Article |
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2
(CQD-NH
2
)). Although these CQDs have very low toxicity towards HeLa cells, they still increase the cell membrane permeability by 8%, 13%, and 19% for CQD-PEG, CQD-OH, and CQD-NH
2
, respectively, and this kind of permeability was irreversible. These observations are valuable for promoting the bio-applications of carbon nanostructures in living systems.
Low toxicity and biocompatible CQDs with different surfaces show different effects on the increasing cell membrane permeability.</description><identifier>ISSN: 2040-3364</identifier><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/c3nr06590a</identifier><identifier>PMID: 24722927</identifier><language>eng</language><publisher>England</publisher><subject>Carbon ; Carbon - chemistry ; Cell Membrane Permeability ; Functional groups ; HeLa Cells ; Humans ; Materials Testing ; Membranes ; Nanostructure ; Permeability ; Quantum dots ; Quantum Dots - chemistry ; Real time ; Toxicity</subject><ispartof>Nanoscale, 2014-05, Vol.6 (1), p.5116-512</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-578837bd68aedd5b28da1ec54d6a9e7249556e183b81da5b3ddd50e290496e233</citedby><cites>FETCH-LOGICAL-c368t-578837bd68aedd5b28da1ec54d6a9e7249556e183b81da5b3ddd50e290496e233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24722927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, Weiqian</creatorcontrib><creatorcontrib>Liu, Juan</creatorcontrib><creatorcontrib>Liu, Ruihua</creatorcontrib><creatorcontrib>Li, Hao</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Huang, Hui</creatorcontrib><creatorcontrib>Li, Kunyang</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Lee, Shuit-Tong</creatorcontrib><creatorcontrib>Kang, Zhenhui</creatorcontrib><title>Quantitative and real-time effects of carbon quantum dots on single living HeLa cell membrane permeability</title><title>Nanoscale</title><addtitle>Nanoscale</addtitle><description>The interaction between carbon quantum dots (CQDs) and a single living cell was explored in real time. Here, we provide the quantitative data on the permeability of the HeLa cell membrane in the presence of CQDs with different surface functional groups (CQDs terminated with -OH/-COOH (CQD-OH), -PEG (CQD-PEG), and -NH
2
(CQD-NH
2
)). Although these CQDs have very low toxicity towards HeLa cells, they still increase the cell membrane permeability by 8%, 13%, and 19% for CQD-PEG, CQD-OH, and CQD-NH
2
, respectively, and this kind of permeability was irreversible. These observations are valuable for promoting the bio-applications of carbon nanostructures in living systems.
Low toxicity and biocompatible CQDs with different surfaces show different effects on the increasing cell membrane permeability.</description><subject>Carbon</subject><subject>Carbon - chemistry</subject><subject>Cell Membrane Permeability</subject><subject>Functional groups</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Materials Testing</subject><subject>Membranes</subject><subject>Nanostructure</subject><subject>Permeability</subject><subject>Quantum dots</subject><subject>Quantum Dots - chemistry</subject><subject>Real time</subject><subject>Toxicity</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M1LwzAYBvAgipvTi3cl3kSopkmatkcZ6oSBCHouSfNWMvq1JB3svzdlc7t5SV6SHw8vD0LXMXmMCcufStZaIpKcyBM0pYSTiLGUnh5mwSfowrkVISJngp2jCeUppTlNp2j1OcjWGy-92QCWrcYWZB150wCGqoLSO9xVuJRWdS1ej3hosO7G5xY70_7UgGuzCQNewFLiEuoaN9AoK1vAPdgGpDK18dtLdFbJ2sHV_p6h79eXr_kiWn68vc-fl1HJROajJM0yliotMglaJ4pmWsZQJlwLmUNKeZ4kAuKMqSzWMlFMB0WA5oTnAihjM3S_y-1ttx7A-aIxblwrLNQNrogTHnMeThHow46WtnPOQlX01jTSbouYFGO3xbHbgG_3uYNqQB_oX5kB3O2AdeXh9xhQ9LoK5uY_w34Bt3SLJQ</recordid><startdate>20140521</startdate><enddate>20140521</enddate><creator>Kong, Weiqian</creator><creator>Liu, Juan</creator><creator>Liu, Ruihua</creator><creator>Li, Hao</creator><creator>Liu, Yang</creator><creator>Huang, Hui</creator><creator>Li, Kunyang</creator><creator>Liu, Jian</creator><creator>Lee, Shuit-Tong</creator><creator>Kang, Zhenhui</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140521</creationdate><title>Quantitative and real-time effects of carbon quantum dots on single living HeLa cell membrane permeability</title><author>Kong, Weiqian ; Liu, Juan ; Liu, Ruihua ; Li, Hao ; Liu, Yang ; Huang, Hui ; Li, Kunyang ; Liu, Jian ; Lee, Shuit-Tong ; Kang, Zhenhui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-578837bd68aedd5b28da1ec54d6a9e7249556e183b81da5b3ddd50e290496e233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Carbon</topic><topic>Carbon - chemistry</topic><topic>Cell Membrane Permeability</topic><topic>Functional groups</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Materials Testing</topic><topic>Membranes</topic><topic>Nanostructure</topic><topic>Permeability</topic><topic>Quantum dots</topic><topic>Quantum Dots - chemistry</topic><topic>Real time</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Weiqian</creatorcontrib><creatorcontrib>Liu, Juan</creatorcontrib><creatorcontrib>Liu, Ruihua</creatorcontrib><creatorcontrib>Li, Hao</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Huang, Hui</creatorcontrib><creatorcontrib>Li, Kunyang</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Lee, Shuit-Tong</creatorcontrib><creatorcontrib>Kang, Zhenhui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Weiqian</au><au>Liu, Juan</au><au>Liu, Ruihua</au><au>Li, Hao</au><au>Liu, Yang</au><au>Huang, Hui</au><au>Li, Kunyang</au><au>Liu, Jian</au><au>Lee, Shuit-Tong</au><au>Kang, Zhenhui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative and real-time effects of carbon quantum dots on single living HeLa cell membrane permeability</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2014-05-21</date><risdate>2014</risdate><volume>6</volume><issue>1</issue><spage>5116</spage><epage>512</epage><pages>5116-512</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>The interaction between carbon quantum dots (CQDs) and a single living cell was explored in real time. Here, we provide the quantitative data on the permeability of the HeLa cell membrane in the presence of CQDs with different surface functional groups (CQDs terminated with -OH/-COOH (CQD-OH), -PEG (CQD-PEG), and -NH
2
(CQD-NH
2
)). Although these CQDs have very low toxicity towards HeLa cells, they still increase the cell membrane permeability by 8%, 13%, and 19% for CQD-PEG, CQD-OH, and CQD-NH
2
, respectively, and this kind of permeability was irreversible. These observations are valuable for promoting the bio-applications of carbon nanostructures in living systems.
Low toxicity and biocompatible CQDs with different surfaces show different effects on the increasing cell membrane permeability.</abstract><cop>England</cop><pmid>24722927</pmid><doi>10.1039/c3nr06590a</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Nanoscale, 2014-05, Vol.6 (1), p.5116-512 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Carbon Carbon - chemistry Cell Membrane Permeability Functional groups HeLa Cells Humans Materials Testing Membranes Nanostructure Permeability Quantum dots Quantum Dots - chemistry Real time Toxicity |
| title | Quantitative and real-time effects of carbon quantum dots on single living HeLa cell membrane permeability |
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