Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate

Nanoparticle (NP)-based targeted drug delivery involves cell-specific targeting followed by a subsequent therapeutic action from the therapeutic carried by the NP system. NPs conjugated with methotrexate (MTX), a potent inhibitor of dihydrofolate reductase (DHFR) localized in cytosol, have been unde...

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Veröffentlicht in:	Photochemical & photobiological sciences 2012-04, Vol.11 (4), p.653-66
Hauptverfasser:	Choi, Seok Ki, Thomas, Thommey P, Li, Ming-Hsin, Desai, Ankur, Kotlyar, Alina, Baker, James R
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biochemistry Biomaterials Cell Line, Tumor Chemistry Dendrimers - chemistry Folic Acid Antagonists - chemical synthesis Folic Acid Antagonists - chemistry Folic Acid Antagonists - toxicity Humans Methotrexate - toxicity Nanoconjugates - chemistry Nanoconjugates - toxicity Neoplasms - drug therapy Photolysis Physical Chemistry Plant Sciences Spectrophotometry, Ultraviolet Tetrahydrofolate Dehydrogenase - chemistry Tetrahydrofolate Dehydrogenase - metabolism Ultraviolet Rays
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