Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol: Intriguing substituent effects, their toxicological and chemopreventive implications

The syntheses of fourteen unusual o-carboxamido stilbenes by the Heck protocol revealed surprising complexity related to intriguing substituent effects with mechanistic implications. The unexpected cytotoxic and chemopreventive properties also seem to be substituent dependent. For example, although...

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Veröffentlicht in:	Organic & biomolecular chemistry 2010-12, Vol.8 (24), p.5646
Hauptverfasser:	Kee, Chin Hui, Ariffin, Azhar, Awang, Khalijah, Takeya, Koichi, Morita, Hiroshi, Hussain, Salmaan Inayat, Chan, Kok Meng, Wood, Pauline J, Threadgill, Michael D, Lim, Chuan Gee, Ng, Seikweng, Weber, Jean Frédéric F, Thomas, Noel F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Catalysis Cell Line Cell Survival - drug effects HT29 Cells Humans Oxidation-Reduction Palladium - chemistry Stilbenes - chemical synthesis Stilbenes - pharmacology Structure-Activity Relationship
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