Real-time fluorescence monitoring of phenothiazinium photosensitizers and their anti-mycobacterial photodynamic activity against Mycobacterium bovis BCG in in vitro and in vivo models of localized infection

An objective was to explore the photodynamic activity of two cationic photosensitizers (PS) (benzo[a]phenothiazinium chloride and benzo[a]phenoselenazinium chloride) against Mycobacterium bovis BCG both in vitro and in a murine model of BCG-granuloma. The hypothesis being tested in this study was th...

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Veröffentlicht in:	Photochemical & photobiological sciences 2007-10, Vol.6 (10), p.1117-1123
Hauptverfasser:	O'Riordan, Katie, Akilov, Oleg E, Chang, Sung K, Foley, James W, Hasan, Tayyaba
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Fluorescence Granuloma - drug therapy Granuloma - microbiology Mice Mice, Inbred BALB C Microscopy, Fluorescence - methods Mycobacterium bovis - drug effects Organoselenium Compounds - pharmacology Organoselenium Compounds - therapeutic use Photochemotherapy Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Thiazines - pharmacology Thiazines - therapeutic use Tuberculosis - drug therapy Tuberculosis - microbiology
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