Deep-tissue NIR-II bioimaging performance of Si-based and InGaAs-based imaging devices using short-wave infrared persistent luminescence
Bioimaging in the second near-infrared (NIR-II; 950-1700 nm) window, employing InGaAs-based cameras, exhibits superior clarity and resolution in visualizing shallow structures (
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| Veröffentlicht in: | Journal of materials chemistry. C, Materials for optical and electronic devices Materials for optical and electronic devices, 2024, Vol.12 (21), p.7542-7551 |
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| container_title | Journal of materials chemistry. C, Materials for optical and electronic devices |
| container_volume | 12 |
| creator | Chen, Yafei Spinelli, Simona Pan, Zhengwei |
| description | Bioimaging in the second near-infrared (NIR-II; 950-1700 nm) window, employing InGaAs-based cameras, exhibits superior clarity and resolution in visualizing shallow structures ( |
| doi_str_mv | 10.1039/d4tc01323a |
| format | Article |
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short-wave infrared (SWIR) persistent luminescent phosphor emitting at 950-1100 nm as a contrast agent to assess the deep-tissue bioimaging capabilities of both an InGaAs camera and a Si CCD camera under identical imaging conditions in thick chicken breast tissues (5-20 mm), thick mice bodies (10-20 mm), and internal mice organs (gastrointestinal tracts, lungs, and livers). Despite the significantly higher quantum efficiency of the InGaAs camera (∼80-85%) compared to the Si camera (∼5-30%) in detecting 950-1100 nm SWIR light, the former exhibits notably inferior performance overall in imaging deep-tissue features, particularly in scenarios with faint imaging signals, attributable to the pronounced interference of its inherently high dark current. Nonetheless, when provided with sufficiently intense SWIR imaging signals, the InGaAs camera outperforms the Si camera in terms of clarity, even in chicken tissues of 10 mm thickness and in the stomachs of mice.
Deep-tissue NIR-II bioimaging performance of Si CCD and InGaAs FPA cameras was evaluated under identical imaging-signal-only tissue environment using 950-1100 nm SWIR persistent luminescence signals from MgGeO
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nanoparticles (NPs).</description><identifier>ISSN: 2050-7526</identifier><identifier>EISSN: 2050-7534</identifier><identifier>DOI: 10.1039/d4tc01323a</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Cameras ; CCD cameras ; Chickens ; Contrast agents ; Dark current ; Luminescence ; Medical imaging ; Near infrared radiation ; Phosphors ; Quantum efficiency ; Short wave radiation</subject><ispartof>Journal of materials chemistry. C, Materials for optical and electronic devices, 2024, Vol.12 (21), p.7542-7551</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c240t-e93ad3a9dd334e7a3f8e3f59974708c0b573b73245d1c7f8651612fcb698806c3</cites><orcidid>0000-0002-3854-958X ; 0000-0002-2409-2048</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Chen, Yafei</creatorcontrib><creatorcontrib>Spinelli, Simona</creatorcontrib><creatorcontrib>Pan, Zhengwei</creatorcontrib><title>Deep-tissue NIR-II bioimaging performance of Si-based and InGaAs-based imaging devices using short-wave infrared persistent luminescence</title><title>Journal of materials chemistry. C, Materials for optical and electronic devices</title><description>Bioimaging in the second near-infrared (NIR-II; 950-1700 nm) window, employing InGaAs-based cameras, exhibits superior clarity and resolution in visualizing shallow structures (<3 mm), yet it falls short in effectively imaging deep-tissue features. The subpar performance of deep-tissue NIR-II imaging is largely attributed to shortcomings in imaging contrast agents, primarily concerning their luminescence brightness and wavelengths, with minimal consideration given to deficiencies in InGaAs cameras. Here, we use a MgGeO
3
:Yb
3+
short-wave infrared (SWIR) persistent luminescent phosphor emitting at 950-1100 nm as a contrast agent to assess the deep-tissue bioimaging capabilities of both an InGaAs camera and a Si CCD camera under identical imaging conditions in thick chicken breast tissues (5-20 mm), thick mice bodies (10-20 mm), and internal mice organs (gastrointestinal tracts, lungs, and livers). Despite the significantly higher quantum efficiency of the InGaAs camera (∼80-85%) compared to the Si camera (∼5-30%) in detecting 950-1100 nm SWIR light, the former exhibits notably inferior performance overall in imaging deep-tissue features, particularly in scenarios with faint imaging signals, attributable to the pronounced interference of its inherently high dark current. Nonetheless, when provided with sufficiently intense SWIR imaging signals, the InGaAs camera outperforms the Si camera in terms of clarity, even in chicken tissues of 10 mm thickness and in the stomachs of mice.
Deep-tissue NIR-II bioimaging performance of Si CCD and InGaAs FPA cameras was evaluated under identical imaging-signal-only tissue environment using 950-1100 nm SWIR persistent luminescence signals from MgGeO
3
:Yb
3+
nanoparticles (NPs).</description><subject>Cameras</subject><subject>CCD cameras</subject><subject>Chickens</subject><subject>Contrast agents</subject><subject>Dark current</subject><subject>Luminescence</subject><subject>Medical imaging</subject><subject>Near infrared radiation</subject><subject>Phosphors</subject><subject>Quantum efficiency</subject><subject>Short wave radiation</subject><issn>2050-7526</issn><issn>2050-7534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpFkd9LwzAQx4MoOOZefBcCvgnVtEnT9nFsOgtDQedzSZPLzNjammsn_gf-2XZuznu5H3zue9wdIZchuw0Zz-6MaDULecTVCRlELGZBEnNxeowjeU5GiCvWWxrKVGYD8j0FaILWIXZAn_KXIM9p6Wq3UUtXLWkD3tZ-oyoNtLb01QWlQjBUVYbm1UyN8VD4azCwdRqQdrjL8L32bfCptkBdZb3yPdlLosMWqpauu42rADX08hfkzKo1wujgh-Tt4X4xeQzmz7N8Mp4HOhKsDSDjynCVGcO5gERxmwK3cZYlImGpZmWc8DLhkYhNqBObyjiUYWR1KbM0ZVLzIbne6za-_ugA22JVd77qRxacSRHxmKVZT93sKe1rRA-2aHy_ov8qQlbsjl1MxWLye-xxD1_tYY_6yP0_g_8AzPx8JQ</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Chen, Yafei</creator><creator>Spinelli, Simona</creator><creator>Pan, Zhengwei</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-3854-958X</orcidid><orcidid>https://orcid.org/0000-0002-2409-2048</orcidid></search><sort><creationdate>2024</creationdate><title>Deep-tissue NIR-II bioimaging performance of Si-based and InGaAs-based imaging devices using short-wave infrared persistent luminescence</title><author>Chen, Yafei ; Spinelli, Simona ; Pan, Zhengwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c240t-e93ad3a9dd334e7a3f8e3f59974708c0b573b73245d1c7f8651612fcb698806c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cameras</topic><topic>CCD cameras</topic><topic>Chickens</topic><topic>Contrast agents</topic><topic>Dark current</topic><topic>Luminescence</topic><topic>Medical imaging</topic><topic>Near infrared radiation</topic><topic>Phosphors</topic><topic>Quantum efficiency</topic><topic>Short wave radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yafei</creatorcontrib><creatorcontrib>Spinelli, Simona</creatorcontrib><creatorcontrib>Pan, Zhengwei</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of materials chemistry. C, Materials for optical and electronic devices</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yafei</au><au>Spinelli, Simona</au><au>Pan, Zhengwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deep-tissue NIR-II bioimaging performance of Si-based and InGaAs-based imaging devices using short-wave infrared persistent luminescence</atitle><jtitle>Journal of materials chemistry. C, Materials for optical and electronic devices</jtitle><date>2024</date><risdate>2024</risdate><volume>12</volume><issue>21</issue><spage>7542</spage><epage>7551</epage><pages>7542-7551</pages><issn>2050-7526</issn><eissn>2050-7534</eissn><abstract>Bioimaging in the second near-infrared (NIR-II; 950-1700 nm) window, employing InGaAs-based cameras, exhibits superior clarity and resolution in visualizing shallow structures (<3 mm), yet it falls short in effectively imaging deep-tissue features. The subpar performance of deep-tissue NIR-II imaging is largely attributed to shortcomings in imaging contrast agents, primarily concerning their luminescence brightness and wavelengths, with minimal consideration given to deficiencies in InGaAs cameras. Here, we use a MgGeO
3
:Yb
3+
short-wave infrared (SWIR) persistent luminescent phosphor emitting at 950-1100 nm as a contrast agent to assess the deep-tissue bioimaging capabilities of both an InGaAs camera and a Si CCD camera under identical imaging conditions in thick chicken breast tissues (5-20 mm), thick mice bodies (10-20 mm), and internal mice organs (gastrointestinal tracts, lungs, and livers). Despite the significantly higher quantum efficiency of the InGaAs camera (∼80-85%) compared to the Si camera (∼5-30%) in detecting 950-1100 nm SWIR light, the former exhibits notably inferior performance overall in imaging deep-tissue features, particularly in scenarios with faint imaging signals, attributable to the pronounced interference of its inherently high dark current. Nonetheless, when provided with sufficiently intense SWIR imaging signals, the InGaAs camera outperforms the Si camera in terms of clarity, even in chicken tissues of 10 mm thickness and in the stomachs of mice.
Deep-tissue NIR-II bioimaging performance of Si CCD and InGaAs FPA cameras was evaluated under identical imaging-signal-only tissue environment using 950-1100 nm SWIR persistent luminescence signals from MgGeO
3
:Yb
3+
nanoparticles (NPs).</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d4tc01323a</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3854-958X</orcidid><orcidid>https://orcid.org/0000-0002-2409-2048</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2050-7526 |
| ispartof | Journal of materials chemistry. C, Materials for optical and electronic devices, 2024, Vol.12 (21), p.7542-7551 |
| issn | 2050-7526 2050-7534 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D4TC01323A |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Cameras CCD cameras Chickens Contrast agents Dark current Luminescence Medical imaging Near infrared radiation Phosphors Quantum efficiency Short wave radiation |
| title | Deep-tissue NIR-II bioimaging performance of Si-based and InGaAs-based imaging devices using short-wave infrared persistent luminescence |
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