Disturbing microtubule-endoplasmic reticulum dynamics by gold nanoclusters for improved triple-negative breast cancer treatment

Microtubules are highly dynamic structures, and their dynamic instability is indispensable for not only cell growth and movement, but also stress responses, such as endoplasmic reticulum (ER) stress. Docetaxel, a microtubule targeting agent (MTA), is the first-line drug for cancer treatment by simul...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-11, Vol.12 (45), p.11648-11658
Hauptverfasser:	Cao, Kai, Luo, Kaidi, Zheng, Yichen, Xue, Liyuan, Huo, Wendi, Ruan, Panpan, Wang, Yuchen, Xue, Yilin, Yao, Xiuxiu, Xia, Dongfang, Gao, Xueyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Breast cancer Cancer therapies Cell death Cell Line, Tumor Cell migration Cell Proliferation - drug effects Cellular stress response Cytokines Docetaxel - chemistry Docetaxel - pharmacology Drug resistance Drug Screening Assays, Antitumor Dynamic stability Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - drug effects Female Gold Gold - chemistry Gold - pharmacology Humans Metal Nanoparticles - chemistry Mice Mice, Inbred BALB C Mice, Nude Microtubules Microtubules - drug effects Microtubules - metabolism Mortality Nanoclusters Nanomaterials Structural stability Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - pathology Tumors
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