Harnessing a bis-electrophilic boronic acid lynchpin for azaborolo thiazolidine (ABT) grafting in cyclic peptides

Chemical modifications of native peptides have significantly advanced modern drug discovery in recent decades. On this front, the installation of multitasking molecular grafts onto macrocyclic peptides offers numerous opportunities in biomedical applications. Here, we showcase a new class of borono-...

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Veröffentlicht in:	Chemical science (Cambridge) 2024-08, Vol.15 (34), p.13688-13698
Hauptverfasser:	Das, Basab Kanti, Chowdhury, Arnab, Chatterjee, Saurav, Tripathi, Nitesh Mani, Pati, Bibekananda, Dutta, Soumit, Bandyopadhyay, Anupam
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical materials Chemistry Conjugation Crosslinking Cysteine Grafting Multitasking Nucleophiles Peptides Regioselectivity
Online-Zugang:	Volltext
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