Bisindole-based small molecules as transmembrane anion transporters and potential anticancer agents

Few synthetic ion transporters have been reported incorporating indole as the core moiety. We have developed a novel bisindole-based transporter capable of efficient transmembrane anion antiport. This system induced cytotoxicity in MCF-7 breast cancer cells via chloride ion homeostasis disruption an...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic & biomolecular chemistry 2024-06, Vol.22 (24), p.4987-4992
Hauptverfasser:	Salunke, Swati Bansi, Save, Shreyada N, Roy, Naveen J, Naorem, Ronedy, Sharma, Shilpy, Talukdar, Pinaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions Antineoplastic drugs Antiport Chloride ions Cytotoxicity Depolarization Homeostasis Membrane potential
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!