Combinatorial synthesis of substituted pyrazolo-fused quinazolines by the Rh(III)-catalyzed [5 + 1] annulation of phenyl-1 H -pyrazol-5-amine with alkynoates and alkynamides

A Rh(III)-catalyzed C-H activation/cyclization cascade was developed for the first divergent synthesis of pyrazolo[1,5- ]quinazolines through a [5 + 1] annulation reaction exclusively. The one-pot procedure is recognized for its broad substrate scope, functional group tolerance, and high atom econom...

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Veröffentlicht in:	Organic & biomolecular chemistry 2024-08, Vol.22 (33), p.6841-6846
Hauptverfasser:	Chiu, Wei-Jung, Chu, Ting-Yen, Sun, Chung-Ming
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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