Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth() gallate and bismuth citrate

Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth() gallate and bismuth citrate

Organobismuth compounds have been known for centuries as substances of medical interest, and continue to be used in medicine today. Bismuth active pharmaceutical ingredients (APIs) are used as digestive aids, including in combating Helicobacter pylori , showing antiviral properties. Here we report t...

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Veröffentlicht in:RSC Mechanochemistry 2024-07, Vol.1 (3), p.255-262
Hauptverfasser: Szczerba, Daniel, Do, Jean-Louis, Tan, Davin, Titi, Hatem M, Geoffroy, Nicolas, Lucas, María del Carmen Marco de, Boudon, Julien, Halasz, Ivan, Friš i, Tomislav, Kimber, Simon A. J
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container_issue 3
container_start_page 255
container_title RSC Mechanochemistry
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creator Szczerba, Daniel
Do, Jean-Louis
Tan, Davin
Titi, Hatem M
Geoffroy, Nicolas
Lucas, María del Carmen Marco de
Boudon, Julien
Halasz, Ivan
Friš i, Tomislav
Kimber, Simon A. J
description Organobismuth compounds have been known for centuries as substances of medical interest, and continue to be used in medicine today. Bismuth active pharmaceutical ingredients (APIs) are used as digestive aids, including in combating Helicobacter pylori , showing antiviral properties. Here we report the mechanochemical synthesis of bismuth gallate and bismuth citrate. In addition, we revisit the previously reported mechanochemical synthesis of bismuth( iii ) di- and trisalicylate. In the case of bismuth citrate, which has an unknown structure, we show that hydration induces a reversible transformation to a large (possibly cubic) unit cell. Organobismuth compounds have been known for centuries as substances of medical interest, and continue to be used in medicine today.
doi_str_mv 10.1039/d4mr00008k
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title Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth() gallate and bismuth citrate
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