Sidechain structure-activity relationships of cyclobutane-based small molecule αvβ3 antagonists

The integrin family of cell surface extracellular matrix binding proteins are key to several physiological processes involved in tissue development, as well as cancer proliferation and dissemination. They are therefore attractive targets for drug discovery with cancer and non-cancer applications. We...

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Veröffentlicht in:	MedChemComm 2024-10, Vol.15 (1), p.3616-3624
Hauptverfasser:	Throup, Adam, Zraikat, Manar Saleh, Gordon, Andrew, Jafarinejad Soumehsaraei, Shohreh, Haase, Kathrin D, Patterson, Laurence H, Cooper, Patricia A, Hanlon, Katherine, Loadman, Paul M, Sutherland, Mark, Shnyder, Steven D, Sheldrake, Helen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aspartic acid Cancer Carboxylic acids Cell surface Cyclobutane Drug development Drug discovery Extracellular matrix Glycine In vivo methods and tests Lead compounds Molecular structure Synthesis
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