Exploring cancer-associated fibroblast-induced resistance to tyrosine kinase inhibitors in hepatoma cells using a liver-on-a-chip model

Liver cancer is a significant global contributor to cancer-related mortality. Despite available targeted therapies, resistance to tyrosine kinase inhibitors (TKIs) like sorafenib and lenvatinib poses a formidable challenge. The tumor microenvironment (TME), inhabited by cancer-associated fibroblasts...

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Veröffentlicht in:	Lab on a chip 2024-10, Vol.24 (21), p.543-554
Hauptverfasser:	Poddar, Madhu Shree, Chu, Yu-De, Pendharkar, Gaurav, Liu, Cheng-Hsien, Yeh, Chau-Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Drug resistance Fibroblasts Functional testing Kinases Liver cancer Microfluidics Replication Tyrosine
Online-Zugang:	Volltext
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