CuBr 2 -mediated dehydrogenative [4+2] annulation of 1-naphthyl-1,3-indandiones and alkenes

CuBr 2 -mediated dehydrogenative [4+2] annulation of 1-naphthyl-1,3-indandiones and alkenes

Intermolecular annulation reactions of 1-naphthyl-1,3-indandiones with alkenes proceed efficiently in the presence of a copper catalyst to generate spirocarbocycle compounds. Various spirocyclic molecules bearing an all-carbon quaternary center could be obtained by this novel method with good yields...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2024-08, Vol.60 (68), p.9070-9073
Hauptverfasser: Zhang, Xu, Chang, Mengfan, Ni, Tongtong, Liu, Shuhan, Li, Wenguang, Xu, Xuefeng
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container_issue 68
container_start_page 9070
container_title Chemical communications (Cambridge, England)
container_volume 60
creator Zhang, Xu
Chang, Mengfan
Ni, Tongtong
Liu, Shuhan
Li, Wenguang
Xu, Xuefeng
description Intermolecular annulation reactions of 1-naphthyl-1,3-indandiones with alkenes proceed efficiently in the presence of a copper catalyst to generate spirocarbocycle compounds. Various spirocyclic molecules bearing an all-carbon quaternary center could be obtained by this novel method with good yields, excellent regioselectivity, and good functional group tolerance. A radical mechanism is proposed based on the HRMS analysis results of control experiments.
doi_str_mv 10.1039/D4CC02386B
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title CuBr 2 -mediated dehydrogenative [4+2] annulation of 1-naphthyl-1,3-indandiones and alkenes
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