Synthesis and stability of the [ 45 Ti]Ti-DOTA complex: en route towards aza-macrocyclic 45 Ti-based radiopharmaceuticals

Synthesis and stability of the [ 45 Ti]Ti-DOTA complex: en route towards aza-macrocyclic 45 Ti-based radiopharmaceuticals

We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with Ti, a guaiacol-based liquid-liquid extraction method, leads to a high...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2024-07, Vol.60 (56), p.7148-7151
Hauptverfasser: Roy, Tamal, Pogorilyy, Eduard, Kumarananthan, Chubina P, Kvitastein, Unni A, Foscato, Marco, Törnroos, Karl W, Adamsen, Tom C H, Le Roux, Erwan
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container_issue 56
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container_title Chemical communications (Cambridge, England)
container_volume 60
creator Roy, Tamal
Pogorilyy, Eduard
Kumarananthan, Chubina P
Kvitastein, Unni A
Foscato, Marco
Törnroos, Karl W
Adamsen, Tom C H
Le Roux, Erwan
description We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with Ti, a guaiacol-based liquid-liquid extraction method, leads to a high radiochemical conversion up to 98%.
doi_str_mv 10.1039/d4cc01800a
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title Synthesis and stability of the [ 45 Ti]Ti-DOTA complex: en route towards aza-macrocyclic 45 Ti-based radiopharmaceuticals
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