FEN1-assisted DNA logic amplifier circuit for fast and compact DNA computing
This work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and 4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification reaction, for the fastest and compact DNA computing. Moreover, the logic circuit can use input strands with concentrations...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2024-04, Vol.6 (34), p.4593-4596 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Xiang, Zheng Zheng, Jia-Yi Ma, Xueping Chu, Yanan Song, Qinxin Zhou, Guohua Zou, Bingjie Wu, Haiping Wang, Chen |
| description | This work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and 4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification reaction, for the fastest and compact DNA computing. Moreover, the logic circuit can use input strands with concentrations of less than 1 nM, which is more than 100 times lower than the input concentration of other DNA logic circuits, providing a promising methodology for constructing fast and compact DNA computations.
This work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and 4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification reaction, for the fastest and compact DNA computing. |
| doi_str_mv | 10.1039/d4cc00203b |
| format | Article |
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This work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and 4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification reaction, for the fastest and compact DNA computing.</description><subject>Amplifiers</subject><subject>Computation</subject><subject>Fanout</subject><subject>Gates (circuits)</subject><subject>Logic circuits</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpd0UlLAzEUB_Agiq3Vi3dlwIsIo8lkmeRYp60KpV4UvA2ZLCVlNpOZg9_e6aKCubwH-eUR_g-ASwTvEcTiQROlIEwgLo7AGGFGYkr4x_G2pyJOMaEjcBbCBg4HUX4KRpjTNOWMjcFyMV-hWIbgQmd0NFtNo7JZOxXJqi2ddcZHynnVuy6yjY-sDF0kax2ppmql6nYPtn3fuXp9Dk6sLIO5ONQJeF_M37LnePn69JJNl7FKBOtiQ4kyHEGeUoa45JZLZgTVyEqTCJIiUhRMm5RqKDCHCmJLELM41RqyRAk8Abf7ua1vPnsTurxyQZmylLVp-pBjiElCEsTgQG_-0U3T-3r43aAIThNGBR7U3V4p34Tgjc1b7yrpv3IE823G-Yxk2S7jxwFfH0b2RWX0L_0JdQBXe-CD-r39WxL-BhwhfcY</recordid><startdate>20240423</startdate><enddate>20240423</enddate><creator>Xiang, Zheng</creator><creator>Zheng, Jia-Yi</creator><creator>Ma, Xueping</creator><creator>Chu, Yanan</creator><creator>Song, Qinxin</creator><creator>Zhou, Guohua</creator><creator>Zou, Bingjie</creator><creator>Wu, Haiping</creator><creator>Wang, Chen</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6675-4452</orcidid><orcidid>https://orcid.org/0000-0003-1056-9156</orcidid></search><sort><creationdate>20240423</creationdate><title>FEN1-assisted DNA logic amplifier circuit for fast and compact DNA computing</title><author>Xiang, Zheng ; Zheng, Jia-Yi ; Ma, Xueping ; Chu, Yanan ; Song, Qinxin ; Zhou, Guohua ; Zou, Bingjie ; Wu, Haiping ; Wang, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-e54ce810875618a8f8a6e95d1fae294714bb6de75d09380c03f416f37dd062c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amplifiers</topic><topic>Computation</topic><topic>Fanout</topic><topic>Gates (circuits)</topic><topic>Logic circuits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiang, Zheng</creatorcontrib><creatorcontrib>Zheng, Jia-Yi</creatorcontrib><creatorcontrib>Ma, Xueping</creatorcontrib><creatorcontrib>Chu, Yanan</creatorcontrib><creatorcontrib>Song, Qinxin</creatorcontrib><creatorcontrib>Zhou, Guohua</creatorcontrib><creatorcontrib>Zou, Bingjie</creatorcontrib><creatorcontrib>Wu, Haiping</creatorcontrib><creatorcontrib>Wang, Chen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiang, Zheng</au><au>Zheng, Jia-Yi</au><au>Ma, Xueping</au><au>Chu, Yanan</au><au>Song, Qinxin</au><au>Zhou, Guohua</au><au>Zou, Bingjie</au><au>Wu, Haiping</au><au>Wang, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FEN1-assisted DNA logic amplifier circuit for fast and compact DNA computing</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2024-04-23</date><risdate>2024</risdate><volume>6</volume><issue>34</issue><spage>4593</spage><epage>4596</epage><pages>4593-4596</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>This work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and 4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification reaction, for the fastest and compact DNA computing. Moreover, the logic circuit can use input strands with concentrations of less than 1 nM, which is more than 100 times lower than the input concentration of other DNA logic circuits, providing a promising methodology for constructing fast and compact DNA computations.
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2024-04, Vol.6 (34), p.4593-4596 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D4CC00203B |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amplifiers Computation Fanout Gates (circuits) Logic circuits |
| title | FEN1-assisted DNA logic amplifier circuit for fast and compact DNA computing |
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